基于密码子与互补密码子使用的进化树的重构(英文)  

The Phylogeny Tree Reconstruction Based on the Usage Frequencyof Codons and Corresponding Complementary Codons

作　　者：黄惠芳[1] 庄永龙[2] 陈礼明[1] 林鲁萍[1] 马飞[3] 许晓风[4] 

机构地区：[1]厦门大学生命科学学院,厦门361005 [2]清华大学生物信息研究所,北京100084 [3]辽宁师范大学生命科学学院比较基因组与生物信息学实验室,大连116029 [4]南京师范大学生命科学学院,南京210097

出　　处：《安徽农业大学学报》2005年第3期309-315,共7页Journal of Anhui Agricultural University

基　　金：ThisworkwassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina(No.60305001)andagrantfromtheScienceandTechnologyMinistryofChina(PreliminaryStudyonFunctionalGenomeSystematics)(No.2001CCA01400).

摘　　要：为了更深入地了解密码子与互补密码子使用相关的内涵,70个单细胞和多细胞生物被更进一步的分析。结果得到70种细胞生物具有较高的相关系数平均值(0.5101,标准差是0.1389),表明密码子与其互补密码子使用间确实存在正的使用相关联系,进一步地支持了以前的结果。此外,通过对70个单细胞和多细胞生物在基于密码子与互补密码子使用频率差异,以及配对频率的高低信息的分析基础上,绘制进化树,得到的进化树与传统的进化树非常接近。The hypothesis that a codon bias usage is identical to its complementary codon usage preference has been investigated by using the relationship analysis of codons vs their complementary ones among 70 organisms. Significantly positive usage correlations between codons and their complementary ones were found and its implication in biology was also analyzed. The codoncomplementary codon tree was further built, which fairly exhibited the evolutionary relationship of these organisms. The results not only demonstrated the validity of our hypothesis,but also manifested the usefulness of correlation analysis in studying on codon usage pattern and molecular evolutionary mechanisms of organism.

关 键 词：密码子 互补密码子 使用频率 使用偏爱 相关分析 密码子-互补密码子树 

分 类 号：Q987[生物学—遗传学]