甲硫氨酸依赖与肿瘤治疗  

Methionine Dependency and the Therapy of Tumor

作　　者：刘冀红[1] 曹伟新[1] 

机构地区：[1]上海第二医科大学附属瑞金医院临床营养科,上海200025

出　　处：《肠外与肠内营养》2005年第4期247-250,共4页Parenteral & Enteral Nutrition

摘　　要：多种恶性肿瘤细胞都具有甲硫氨酸依赖性。利用肿瘤细胞对甲硫氨酸依赖性,采用去除甲硫氨酸,或以甲硫氨酸酶、甲硫氨酸前体物、类似物降解或替代甲硫氨酸,降低细胞内甲硫氨酸水平,可达到抑制肿瘤细胞增殖的效果。将上述方法与化疗结合,可增强疗效或是减少其毒副反应,有望成为一种新型抗肿瘤治疗方法。Many malignant tumor have methionine dependency. Methionine restriction can inhibit proliferation of tumors cells by decreasing the level of methionine with depriving methionine, methioninase, homocysteine, and its analogs.Methionine restriction may act synergistically with chemotherapies to increase their efficiency and /or reduce their toxic side effects.Therefore, methionine restriction would become a new cancer treatment.

关 键 词：甲硫氨酸 肿瘤 化疗 

分 类 号：R730.5[医药卫生—肿瘤]