^（153）Sm－EDTMP治疗骨转移瘤的临床观察  

￣(153)Sm-EDTMP for treatment of osseous metastases

作　　者：谭天秩[1] 邓候富[1] 梁正路[1] 

机构地区：[1]华西医科大学附属一院核医学科

出　　处：《中华核医学杂志》1995年第1期23-25,共3页Chinese Journal of Nuclear Medicine

基　　金：国家自然科学基金

摘　　要：用１５３Ｓｍ－乙二胺四甲基膦酸（ＥＤＴＭＰ）治疗１３６例骨转移瘤病人，采用两次给药方法．根据病员的骨摄取率确定用量．治疗后骨痛消失者４９例（３６．０３％），骨痛明显减轻者７７例（５６．６２％），止痛总有效率为９２．６５％．治疗后骨转移灶完全消失者９例（６．６２％），转移灶减少或缩小在５０％以上者１３例（９．５６％），减少或缩小在２５％以上者１６例（１１．７６％），转移灶消失或缩小的总有效率为２７．９４％．提示１５３Ｓｍ－ＥＤＴＭＰ治疗骨转移瘤有一定的临床价值．Abstract With reference to cumulated skeletal uptake,136 patients with disseminated bone metastases underwent a two-dose treatment with ￣(153)Sm-EDTMP.49 patients (36.03%) experienced pain disappearance,and pain relief was obtained in 77 patients (56.62%),so the total emciency amounted to 92.65%.Bone metastases disappeared in 9 patients (6.62%);the size or the number or metastatic foci decreased over 50% in 13 patients (9.56%);a decrease of the number or the size of metastatic fool over 25% in 16 patients (11.76%) was obtained,the total efficiency being 27.94%.Our results demonstrated that patients with disseminated metastases could be effectively treated by using ￣(153)Sm-EDTMP.

关 键 词：钐 乙二胺类 骨肿瘤 放射疗法 

分 类 号：R738.105[医药卫生—肿瘤] R817.8[医药卫生—临床医学]