^（99m）Tc－HMPAOSPECT对偏头痛患者丘脑血流变化的研究  

￣(99m)Tc-HMPAO SPECT THALAMIC BLOOD FLOW STUDY IN MIGRAINE

作　　者：张志坚[1] Ste.,TJ 

机构地区：[1]福建医学院附属第一医院神经病学研究室

出　　处：《中华核医学杂志》1995年第4期236-238,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的：了解偏头痛患者丘脑血流的变化。方法：用９９ｍＴｃ－六甲基两二胺肟和Ｎｏｖｏ－８１０高分辨率ＳＰＥＣＴ仪，以感兴趣区（ＲＯＩ）相对放射性计数百分率（ＲＯＩ％）为指标，对６０例次偏头痛患者的丘脑血流变化作了定量分析。结果：与无预兆偏头痛组的平均ＲＯＩ％值（２４９．Ｉｆ１４．９）相比，预兆偏头痛组ＲＯＩ％升高（２５９．１±１７．１），差异有显著意义（Ｐ＜０．０５）；偏瘫、偏身感觉异常预兆偏头痛组升高更明显（２６３．８±１７．２），差异有极显著性（Ｐ＜０．０１）；而单纯视觉预兆组稍升高（２５５．１±１６．４），差异无显著意义（Ｐ＞０．０５）。结论：偏瘫、偏身感觉异常预兆组丘脑血流升高，原因可能为：①缺血后高灌注。②除丘脑外，其它脑区血流减少。③各种神经、化学性刺激的结果。PURPOSE To investigate the changes of blood flow in the thalami of migraineurs by 99mTc-HMPAO SPECT imaging.METHODS 60 cases with migraine were performed by Novo 810 high-resolution SPECT 30 minutes after injection of 99mTc-HMPAO.The quantitative analysis of SPECT data was based on the irregular ROI% uptake normalized to total slice method.RESULTS There were significantly increased mean% uptake values in migraine with aura (259.1± 17.1),and more significantly in those who experienced hemisensory symptoms and hemiparesis during aura (263.8±17.2),comparied to that of migraine without aura (249.1±14. 9),but there were not statistically significant difference between migraine with only visual disturbance during aura (255.1±16.4)and without aura.CONCLUSION The possible explanations for the increased mean% uptake values in migraineurs who experienced hemisensory symptoms and hemiparesis during aura are.(1)the reactive postischemic hyperemia.(2)excepting thalamus, the regional blood now was decreased.(3)the secondary phenomenon to the various neurogenic and chemical stimuli.

关 键 词：偏头痛 丘脑血流 放射性核素 CT 锝99M 

分 类 号：R747.204[医药卫生—神经病学与精神病学] R817.41[医药卫生—临床医学]