CD44smRNA在大肠癌中表达的研究  

The Study of CD44smRNA Expression in Large Intestine Carcenoma

作　　者：蒋丽娜[1] 薄爱华[2] 张晓丽[2] 丁秀丽[3] 苏华[4] 陈秀玲[4] 张江兰[4] 杨艳君[4] 

机构地区：[1]河北北方学院免疫教研室,河北张家口075000 [2]河北北方学院实验中心,河北张家口075000 [3]中国人民解放军第251医院中心实验室,河北张家口075000 [4]河北北方学院电镜室兴趣小组,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2005年第3期12-13,共2页Journal of Hebei North University:Medical Edition

摘　　要：目的:探讨CD44smRNA在大肠癌细胞中表达的特点。方法:利用核酸原位杂交技术,对52例大肠癌组织进行检测。结果:CD44smRNA在大肠癌中总阳性率为65·38%(34/52)CD44smRNA表达与患者的性别、年龄及分化程度无相关性,而与有否淋巴结转移有一定的相关性。结论:CD44smRNA在大肠癌中有较高表达,可作为临床预测大肠癌转移潜能的一个重要参考指标。Objective:To study the expression char acter of CD44smRNAin large intestine cancer. Methods:The 52 case s of large intestine cancer were examined with in situ hybridization methods. Results:The total positive expression rate of CD44smRNA was 63.46 %(33/52) in large intestin cancer. The CD44smRNA was correlated with patient's a ge, sex and tumor differentiation(P>0.05).There was a significa nt correlation between CD44smRNA and lymph node metastasis(P<0. 05).Conclusion:There was higher expression of CD44 in large int estin cancer.The expression of CD44smRNA may serve as an indicator to predict th e lymph nodes metasis in large intestine carcinoma.

关 键 词：大肠癌 CD44smRNA 原位杂交 

分 类 号：R735.302[医药卫生—肿瘤]