谷胱甘肽转移酶μ基因缺失与肺癌发病的相关性研究  

The study of GSTμ gene del etion as the hereditarymarker for susceptibility to lung Cancer.

作　　者：孙贵范[1] 皮静波[1] 郑全美[1] 郑美珍[1] 原田二 下条信弘 

机构地区：[1]中国医科大学预防医学系,中国医科大学保健科,辽宁省肿瘤医院,日本筑波大学社会医学系

出　　处：《中华结核和呼吸杂志》1995年第3期167-169,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：应用聚合酶链反应（ＰＣＲ）方法，对１７５例肺癌患者及１０４例正常对照者进行了谷胱甘肽转移酶μ（ＧＳＴμ）基因检测。结果发现，在肺场患者中，ＧＳＴμ基因缺失率达７１．４％，显著高于对照组的５１．９％。按病理分型分析表明，各种病理类型的肺癌ＧＳＴμ基因缺失率均高于对照组，尤以小细胞肺癌最高，达７７．５％。按吸烟及年龄对肺癌患者分层分析表明，吸烟与否与ＧＳＴμ基因分布无关，但低年龄组肺癌患者的ＧＳＴμ基因缺失率达８５．３％，显著高于高年龄组的６８．１％，上述结果提示，ＧＳＴμ基因缺失可能是肺癌发生的重要宿主因素之一。totai of 175 lung cancer patients and 104 controlswere detected for GST_μ gene using PCR technique.Theresults showed that the GST_μ gene deletion rate in lungcancer patients was 71.4%, which was significantlyhigher than the controls,51.9%. Analysis according topathological classification of lung cancer indicated thatthe GST_μ gene deletion rate in all three kinds of patho-logical types-squamous,adenocarcinoma and small cellcarcinoma, were markedly higher than that of controls,especially for small cell carcinoma(the delet ion sate is77.5%). The frequency of GST_μ gene was not associ-ated withsmoking in both groups , but the higher defi-ciency rate was found in the low age group of lung can-cer patients, showed 85.3%compared to the high agegroup, 68.1%。 All the results showed that GST_μ genedeletion may be an important host hereditary marker forsusceptibility to lung cancer.

关 键 词：谷胱甘肽转移酶 基因 肺肿瘤 癌 病因 

分 类 号：R734.202[医药卫生—肿瘤]