痰液T抗原检测──一种肺癌筛查的简易新方法  

T antigen test of sputum a new , simple method forthe screening of luug cancer.

作　　者：李昕[1] 戴晓淳[1] 何安光[1] 高华[1] 苏晓林[1] 徐迈[1] 

机构地区：[1]中国医科大学肿瘤研究所

出　　处：《中华结核和呼吸杂志》1995年第5期285-286,共2页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家"八五"攻关基金

摘　　要：为寻求敏感的肺癌诊断方法，采用痰涂膜酶化学法检测１１６例正常人和２１６例良、恶性肺病患者痰液中的Ｔ抗原，结果：１８２例经细胞学或组织学证实的肺癌患者中，１６５例Ｔ抗原阳性，敏感性为９０．７％，１１６例正常对照组中，２２冽出现阳性反应，假阳性率为１９．０％，特异性为８１．０％，２８例核异质患者，２１例检测到Ｔ抗原，其中１５冽经随访证实为肺癌。同时，本研究包括的３例早期肺癌全部阳性，说明：Ｔ抗原在肺癌、早期癌变和癌前病变均有表达，痰液的Ｔ抗原检测是一种较敏感的肺癌诊断方法。he sputum specimens from 116 healthy personsand 216 cases of benign and malignant lung diseaseswere detected for T antigen using a strip test by enzymegalactose oxidaseSchiff sequence. The result shows that165 cases of the 182 patients with lung cancer. con-firmed by cytology and histology, had positive results,whereas 22/116 ( 19. 0% ) of healthy controls were posi-tive. So the sensitivrty was 90. 7% and the specificitywas 81.0%. In 28 cases of patients whose cytology ofsputa showed various degrees of dysplasia, 21 werefound T antigen positive, of which 15 patients were i-dentified to be lung cancer in the follow-up study. Inaddrtion, three cases of early lung cancer in this studywfsrc also positive, suggesting that T antigen was ex-pressed at an earlier stage in the malignant process. Thesludy has indicated that T antigen test of sputum is asensitive method for the diagnosis of lung cancer. Itmay also be a promising approach for the massivescreening of lung cancer in terms of its rapidity, econo-my and simplicity.

关 键 词：肺肿瘤 肿瘤抗原 T抗原 半乳糖氧化酶 诊断 

分 类 号：R734.204[医药卫生—肿瘤]