热暴露附加运动负荷对血浆TXB2，6－K－PGF1_a比值及心肌细胞超微结构的影响  

EFFECTS OF HEAT EXPOSURE AND EXTRA LOAD OF EXERCISE ON THE RATIO OF TXB2 TO 6-k-PGF1a AND ULTRASTRUTURE OF RAT MYOCARDIAL CELLS

作　　者：李继红[1] 辛火[1] 朱国标 丛桦 

机构地区：[1]成都军区临床实验研究所

出　　处：《中华劳动卫生职业病杂志》1995年第1期12-14,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：观察了外界高温（４０℃）附加运动负荷（游泳）对ＳＤ大鼠ＴＸＢ２与６－Ｋ－ＰＧＦ１ａ比值（Ｔ／Ｐ）的影响，结果提示：大鼠受热后体温迅速上升，ＴＸＢ２及６－Ｋ－ＰＧＦ１ａ水平亦增高，以ＴＸＢ２增高幅度较大，各组Ｔ／Ｐ比值与对照组比较差异均有非常显著意义（Ｐ＜０．０１）。大鼠心肌细胞膜结构和功能均有不同程度的破坏：细胞膜通透性增加，Ｎａ－Ｋ－ＡＴＰ酶反应物减少，Ｇ４心肌细胞超微结构损伤更明显，与Ｇ３比较，Ｇ４动物游泳能力明显降低（Ｐ＜０．０１）。还讨论了上述变化的意义和机理。The ratio of the TXB2 to 6-K-PGF1a(T/P)and the ultrastructure of myocardial cells of SD rats were observed after heat,ex-posure(40℃)and extra load of exercise(swimming). The results showed that the rectal temperature of the rats rapidly rose afterheat exposure.TXB2 and 6-K-PGF1a were increased in the experiment,and TXB2 had a higher level. T/P in the experimentalgroups were significantly different from the control group(P<0.01). The function and ultrastructure of the myocardial cell mem-brane were impaired in varying degrees and the permeability of membrane was increased. The activity of Na+,K+-ATPase was re-duced;the swimming ability was also reduced.The mechanism and the signifcance of the above changes were discussed.

关 键 词：热暴露 TXB2 6-K-PGF1A 心肌细胞 超微结构 

分 类 号：R363.123[医药卫生—病理学] R135.3[医药卫生—基础医学]