凋亡相关基因蛋白bcl-2、fas在大肠息肉和肠癌中的表达  

Expression of proapoptosis gene bcl-2 and fas in carcinoma and polyp of large bowel

作　　者：赵秀芳 薄爱华[2] 何玉然 张晓丽[2] 白丽娜[2] 

机构地区：[1]张家口市第六医院,河北张家口075000 [2]河北北方学院,河北张家口075000

出　　处：《现代肿瘤医学》2005年第4期488-490,共3页Journal of Modern Oncology

摘　　要：目的探讨大肠息肉和大肠癌中凋亡相关基因bcl-2和fas表达状况。方法收集大肠炎活检标本30例,腺瘤样息肉28例,大肠腺癌78例;利用SP免疫组织化学方法,检测bcl-2、fas阳性率。结果bcl-2阳性率高于fas;大肠息肉和大肠癌中bcl-2和fas阳性率高于炎症粘膜组织(P<0.05);息肉与癌两组间差异无显著性(P>0.05)。结论粘膜炎症bcl-2和fas很少表达,在息肉和肠癌中表达增多,提示bcl-2和fas参与大肠癌形成过程。Objective To study the expression of proapoptosis gene bcl-2 and fas in colorectal carcinoma and polyp. Methods S-P immunohistochemistry methods were used to defect the expression of bcl-2 and fas in 30 cases of enteritis,28 cases adenomatous polyp and 78 cases of adenocarcinoma. Results The positive rate of bcl-2 was higher than fas.The positive rate of bcl-2 and fas protein were significant higher in polyp and adenocarcinoma than enteritis (P< 0.05).There was no difference in the expression of the two groups between the above polyp and carcinoma (P> 0.05). Conclusion Both the bcl-2 and fas there was low expression in mucosa inflammation.Over-experssion of bcl-2 and fas in polyp and adenocareinoma.The result showed that bcl-2 and fas may play an role in the oncogenesis of large bowed.

关 键 词：炎症 腺瘤样息肉 大肠癌 免疫组织化学 凋亡相关基因 bd-2 FAS 

分 类 号：R734.2[医药卫生—肿瘤]