NP方案治疗晚期非小细胞肺癌的临床观察  

Treatment of advanced non-small cell lung cancer with cisplatin and vinorelbine combination chemotherapy

作　　者：赵文英[1] 

机构地区：[1]皖南医学院弋矶山医院肿瘤内科,安徽芜湖241000

出　　处：《现代肿瘤医学》2005年第4期498-499,共2页Journal of Modern Oncology

摘　　要：目的观察异长春花碱(NVB)、顺铂(DDP)二药联合化疗对晚期非小细胞肺癌(NSCLC)的客观疗效和毒性反应。方法NVB25mg/m2,d1、8,DDP80～100mg/m2,总剂量分为3天使用,d1～3,21天为一周期,按WHO标准评价疗效,同时采用NCICTC标准评价毒性反应。结果所有36例均接受2周期以上化疗,其中PR16例(44.4%),SD16例(44.4%),PD者4例。毒性反应主要是骨髓抑制,其中Ⅲ～Ⅳ度的粒细胞下降28/36(77.8%)。结论NP方案是NSCLC的有效化疗方案,毒性反应可耐受。Objective To observe the object response of patients with advanced non-small cell lung cancer (NSCLC) who treated with a combination chemotherapy of cisplatin and vinorelbine, and also observe their toxicities. Methods Patients received the combination chemotherapy: NVB 25mg/m^2,d1、8,DDP 80~100mg/m^2 devided into 3 days, administrated d1~3,and the therapy cycle comprise 21d. The response rate was estimated according to the standard of WHO,and the toxicities to NCI CTC. Results Of 36 patients who received over two cycles chemotherapy: 16(44.4%)PR, 16(44.4%)SD and 4 PD.The most frequent toxicity was marrow surpression,of which grade 3~4 neurtopenia ocuured in 28/36(77.8%). Conclusion NP combination chemotherapy is efficacious and tolerated in advanced NSCLC。

关 键 词：非小细胞肺癌 异长春花碱 顺铂 联合化疗 

分 类 号：R734.2[医药卫生—肿瘤]