生物工程合成人生长激素释放激素（GHRH_（1－29））对特发性下丘脑性GH缺乏症疗效观察  

THE EFFECT OF RECOMBINANT GH-RELEASING HORMONE(GHRH_(1-29))ON IDIOPATHIC HYPOTHALAMIC GH DEFICIENT PATIENTS

作　　者：沈永年[1] 叶军[1] 陈崇毅[1] 王传丰[1] 谢丹红[1] 乌玉丽[1] 周建德[1] 方锡华 吴蓉芬 黄晓东[1] 陈瑞冠[1] 

机构地区：[1]上海市儿科医学研究所,上海第二医科大学附属新华医院

出　　处：《中华内分泌代谢杂志》1995年第2期83-85,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用ＧＨＲＨ＿（１－２９）每日６０μｇ／ｋｇ、３０μｇ／ｋｇ微泵腹部皮下持续输注，和ＧＨ每日０．１Ｕ／ｋｇ皮下注射治疗特发性下丘脑性ＧＨ缺乏性株儒症各２０例，治疗时间６个月，比较对生长速率的影响。结果表明：３组生长速率均有明显加速，分别为９．１±２．９ｃｍ／年、８．５±２．９ｃｍ／年和１３．８±３．０ｃｍ／年。前３个月治疗效果优于后３个月。ＧＨＲＨ治疗２组，治疗初３个月ＩＧＦ－１浓度持续升高，６个月时恢复到基值，而ＧＨ治疗组，治疗６个月时ＩＧＦ－１仍呈持续上升。ＧＨＲＨ血浓度随治疗时间延长呈持续上升。ＧＨＲＨ激发试验，ＧＨＲＨ治疗前、后６个月时，ＧＨ峰值后者明显大于治疗前基值。最后对上述现象进行了讨论。In this,study, 60 patients with growth hormone deficiency(GHD) of hypothalamic origin were randomized into three equalgroups and received growth hormone-releasing hormone (GHRH_(1-29) ) 60μ/kg·d(group A ),30μg/kg·d(group B)or growth hor-mone(GH) 0.1U/kg·d(group C) respectively for 6 months . GHRH was administered by contintious subctaneous infusion into the anterior abdominal wall with a portable syringe pump and GH was injected,subcutaneously.Height velocity in three groups all accel-erate during this periods. Mean height velocity at 6-month is group A:9.1±2. 9cm/a, group B:8.5±2. 9cm/a,group C:13.8±3.0cm/a.During treatment ,the serum concentration of insulin-like growth factor 1(IGF-1)in group A and B rose initially but feIl tovalues similar to those before treatment, while increased continuously in group C. Plasma GHRH concentrations increased steadilyover the 6-month treatment period. Peak values of GH after GHRH provocative test after treatment are all higher than those be-fore. The results suggest that GHRH may be a potential therapeutic drug for hypothalamic GH deficient patients.

关 键 词：下丘脑 GHRH 生物工程 生长激素缺乏 侏儒症 

分 类 号：R584.210.5[医药卫生—内分泌]