吸入一氧化氮可降低犬急性缺氧性肺动脉高压  

REVERSAT OF ACUTE HYPOXIC PULMONARY HYPERTENSION WITH INHALATION OF NTREIC OXIDE

作　　者：曹伟标[1] 朱元珏[1] 罗慰慈[1] 王再非 姚彬[1] 

机构地区：[1]北京协和医院呼吸科

出　　处：《中华内科杂志》1995年第1期9-12,共4页Chinese Journal of Internal Medicine

摘　　要：观察了一氧化氮吸入对犬急性缺氧性肺动脉高压的影响。结果发现，吸入０．００４４％（即４４ｐｐｍ）一氧化氮可明显降低犬急性缺氧时的肺动脉平均压及肺血管阻力，而对体循环血压及全身血管阻力无影响。提示一氧化氮吸入可用于治疗急性肺动脉高压。he effect of inha1ation of nitric oxide( NO )gas on acutehypoxic pulmonary hypertension was stu-died.Eighteen mongrel dogs were divided into two groups:hypoxic control group(FIO_2=11%,n=10) and NO inhalation group (FIO_2=11%, NO inspiratory concentration n= 44ppm,n=8).In the control group,the increase percent of mean pulmonary arterial pressure(mPAP) was 30.6%±5.5%,47.8%± 11.3%,46.0%±9.3%, 37.0%±6.3%respectively at 5th,15th,30th and 60th minute after hypoxic veritilation. In the NO inhalation group,mPAP increment was 4.6%±3.7%,-0.5%±6.O%,0. 7%± 6.8%,7.2%±6.1%,respectively(all P<0.01,compared with the control group).Inhaled nitric oxide also reduced the pulmonary vascular resistance significantly during hypoxic ventilation,but it had no re-markable effect on the systemic arterial pressure and vascular resistance. These results indicated that in-halation of nitric oxide gas may be used to treat acute hypoxic pulmonary hypertension.

关 键 词：一氧化氮 缺氧症 肺动脉高压 

分 类 号：R543.205[医药卫生—心血管疾病]