幽门螺杆菌破坏胃粘膜屏障的研究  

INVESTIGATION OF DAMAGE OF THE GASTRIC MUCOSAL BARRIER BY HELICOBACTER PY-LORI

作　　者：徐肇敏[1] 张志宏[1] 陈戴融 孙春红[1] 

机构地区：[1]南京鼓楼医院消化科

出　　处：《中华内科杂志》1995年第9期603-605,共3页Chinese Journal of Internal Medicine

摘　　要：为了解幽门螺杆菌（Ｈｐ）对胃粘膜屏障的损伤作用，对５０例Ｈｐ感染的胃炎及５０例非Ｈｐ感染胃炎者测定其胃窦粘膜的磷脂和氮基已糖值，并与病理改变相比较。结果示Ｈｐ感染组胃窦粘膜的磷脂平均值低于非Ｈｐ感染组（Ｐ＜０．０５）。Ｈｐ感染组的胃窦粘膜氨基己糖值明显低于非Ｈｐ感染组（Ｐ＜０．００５）。而Ｈｐ感染组的活动性胃炎明显高于非感染组。结果表明，Ｈｐ可通过破坏胃粘膜屏障而导致胃粘膜炎症性改变。amage of the gastric mucosal barrier by helicobacter pylori(Hp)has been investigated with estima-tion of antral mucosal hexosamine and phospholipid , and the degree of pathologic changes to be also evolut-ed in 100 cases of chronic superficial gastritis. There are 42% of 50 cases of Hp positive patients with active gastric lesions, and significantly high than 50 cases of Hp negative patients(8%).The mean value of antral mucosal hexosamine is 30. 33mg/g in Hp positive group, while in Hp negative group, the mean value is 36.98mg/g(P<0. 005).The mean value of antral mucosal phospholipid is 31.96mg/g in Hp positive,While in Hp negative is 36.49mg/g(P<0.05).So,estimation of mucosal hexosamine and phospholipid can be represent the degree of damage of gastric mucosal barrier. Hp should be considered as causative agent to break down the gastric mucosal barrier.

关 键 词：幽门螺杆菌 胃粘膜 胃炎 磷脂 氨基已糖 

分 类 号：R573.302[医药卫生—消化系统] R378.99[医药卫生—内科学]