动静脉转流重建缺血脑组织循环的实验研究  

Experimental study on the arteriovenous reversal forrevascularization of ischemic brain

作　　者：吴志全[1] 蒋小平[1] 章磷[1] 袭伟光 

机构地区：[1]上海医科大学中山医院,南昌市第一医院

出　　处：《中华外科杂志》1995年第11期701-703,共3页Chinese Journal of Surgery

基　　金：江西省科委与南昌市科委资助课题

摘　　要：将２８只新西兰白兔随机分成实验组（２０只）和对照组（８只）。对照组结扎双侧颈总动脉，实验组在结扎双侧颈总动脉后将右颈总动脉头向转流入面总静脉远侧的颈入静脉，并在手术前后各取入颅动脉和出颅静脉血作血气分析。术后实验组与对照组都均分成四个亚组，分别在术后４８小时与１４天作组织学检查、１４天作脑血管造影并墨汁灌注和长期存活观察。结果，二组动物均存活。实验组手术前后血气无统计学差异（Ｐ＞０．０５），脑血流丰富、通畅，细胞正常；对照组脑血流不足，细胞广泛坏死。作者认为动静脉转流确可重建缺血脑组织循环。AbstractTwenty-eight New Zealand white rabbits wererandomly divided into experimental group(n=20) andcontrol group (n=8).In the experimental group,thebilateral common carotid arteries were ligated, theblood flow of right common carotid artery was reversedinto the right cephalic internal jugular vein distal to thefacial common vein,and the arterial and venous bloodwere obtained from the cerebral circulation pre andpostoperatively for blood gasanalysis. While in the con-trol group,only the bilateral common carotid arterieswere ligated.Both experimental group and controlgroup were further divided equally into 4 subgroups forhistological study at the 48th hour and on the 14th dayafter operatiOn,cerebral angiography and ink injectionon the 14th day of postoperation,and long survival ob-servation, respectively,The results showed that allthe animals survived. In the experimental group,theblood gas analysis revealed no statistical difference(P>0.05) between pre-and postoperation. The cerebralcirculation was rich and patent, and the cerebral cellswere normal. In the control group,however,the cere-bral blood flow was inadequate and the cerebral cellsnecrosed extensively. It is concluded that the adequaterevascularization of ischemic brain can be created bythe arteriovenous reversal.

关 键 词：脑缺血 血管外科手术 动静脉 转流 重建术 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学]