骨肉瘤患者的预后因素  

Prognostic factors in patients with osteosarcoma

作　　者：应明[1] 张文明[1] 刘植珊[1] 高建章[1] 陈永裕[1] 戴益民[1] 

机构地区：[1]第二军医大学长海医院骨科,第二军医大学病理解剖教研室

出　　处：《中华外科杂志》1995年第2期93-96,共4页Chinese Journal of Surgery

摘　　要：作者用单因素分析，多元线性回归和多元逐步回归分析探讨了５４例骨肉瘤患者影响预后的因素。结果表明：肿瘤细胞核ＤＮＡ倍体水平、Ｘ线分级和外科分期是影响患者预后的主要因素：肿瘤部位、肿瘤最大径和以Ｓ期细胞百分数、增殖指数及核仁组成区嗜银蛋白染色表示的肿瘤细胞增殖活性对患者预后具有限的影响。患者年龄、性别、症状持续时间、肿瘤Ｘ线分型和病理分型则与生存率无关。AbstractThe prognostic factors in 54 patients with osteosarcoma were studied by analyses of simple factor,multiple linear regression and stepwise regression. Theresults showed that the significant factors affectingprognosis were tumor cells' DNA content,radiologicalgrade and surgical stage,while tumors' site,maximaldiameter proliferating activity indicated by S-phase cellpercentage,proliferating index and AgNOR counts hadlimited influence on the patients' outcome. Besides,pa-tients' sex,age,duration of the symptom,tumors' radiological classification and pathological type bore norelation to sruvival rate.

关 键 词：骨骼肿瘤 DNA 肉瘤 预后 

分 类 号：R738.107[医药卫生—肿瘤]