人体胆囊结石时胆囊组织PGE、PGI2、LTC4的含量  

THE CONTENT OF PROSTAGLANDINE,PROSTAGLANDIN I2AND LEUKOTRIENEC4 IN THE MUCOSA OF HUMAN GALLBLADDER WITH CHOLESTEROL STONES

作　　者：别平[1] 黄志强[1] 韩本立[1] 杨可桢[1] 王加文[1] 李昆[1] 尹国清 

机构地区：[1]第三军医大学西南医院,解放军总医院

出　　处：《中华消化杂志》1995年第5期262-264,共3页Chinese Journal of Digestion

摘　　要：本文测定非结石组（ｎ＝１６）与结石组（ｎ＝４７）人体胆囊粘膜内前列腺素Ｅ（ＰＧＥ）、前列环素（ＰＧＩ２）白三烯０４（ＬＴＣ４）的含量及磷脂酶Ａ２（ＰＬＡ２）的活性，发现结石组四者的水平均非常显著地高于非结石组。提示可能由于脂类代谢紊乱，胆囊组织的ＰＬＡ２活性增加．致使ＰＧｓ、ＬＴｓ水平增高，引起胆囊上皮细胞活化，合成分泌粘蛋白功能亢进，从而参与促进结石的形成。3 human gallbladders were collected: 16 gallbladders without stone(non-stoe group)and 47 gallbladders with cholesterol stones (stone grou. The levels of prostaglandin E(PGE),prostaglandin I2(PGI2)and leukotriene C4(LTC4) in the gallbladder mucosa weremeasured by radioimmunoassay. Phospholipase A2(PLA2)activity in the mucosa was detectedby acid titration. It was found that in the stone group, the levels of PGE, PGI2 and LTC4 weresignificantly higher than those in the non-stone group (P< 0.001,0.01, 0.00l respective1y).Meanwhile, PLA2 activity in the stone group was significantly increased in comparison withthat in the non-stone group (P< 0.05). These findings suggest that during the formation ofcholesterol gallstones, PLA2 activity may be increased as a result of lipid metabolic disorder.It is likely that the increase in gallbladder PGs and LTs synthesis was closely related to PLA2activity, and they are responsible for mediating gallbladder mucin hypersecretion which canpromote cholesterol gallstone formation.

关 键 词：前列腺素 白三烯C4 磷脂酶A2 胆囊结石 

分 类 号：R575.62[医药卫生—消化系统]