胆囊癌组织中微血管定量及其意义  

THE COUNTING OF MICROVESSEL AND IT’S SIGNIFICANCES IN GALLBIADDER CARCINOMA

作　　者：杨竹林[1] 钟德许[1] 李永国[1] 庄赞根[1] 吕芳[1] 

机构地区：[1]湖南医科大学第二医院

出　　处：《中华消化杂志》1995年第5期273-275,共3页Chinese Journal of Digestion

摘　　要：应用第Ⅷ因子相关抗原的单克隆抗体ＡＢＣ免疫组化，研究４０例胆囊癌组织中微血管。发现低分化腺癌微血管定量，明显高于高分化腺癌和鳞癌，组织学分级Ⅲ级和炎性细胞浸润＋＋级病例微血管定量明显高于组织学分级Ⅰ级和炎性细胞浸润０级病例，转移胆囊癌微血管定量明显高于未转移胆囊癌。结果提示，胆囊癌组织中微血管生成与胆囊癌病理类型、分化程度及炎性细胞浸润有密切关系，高微血管定量胆囊癌易发生转移。The counts of microvessel and it’s significance were investigated by immunohistochemi-cal method of factor Ⅷ related antigen in 40 cases of gallbladder carcinoma, The counts ofmicrovessels were significantly higher in the cases of poorly-differentiated,histologic grade Ⅲ,infiltration of inflammatory cells grade++,and with metastasis than that in the cases ofwell-differentiaed, histologic grade I,infiliation of inflammatory cells grade O,and with outmetastasis. These results suggested angiogenesis in gallbladder carcinoma tissue might berelated to histologic features,and gallbladder carcinoma with high count of microvesselmight be inclined to metastasis with poor-prognosis.

关 键 词：胆囊肿瘤 微血管 免疫组织化学 定量 

分 类 号：R735.8[医药卫生—肿瘤]