小儿神经母细胞瘤DNA含量、N－myc基因扩增与临床预后的关系  

Relation Among DNA Content,N-myc Gene Amplification and the Clinical Prognosis

作　　者：刘荻[1] 吴建新[1] 呼守生[1] 马汝柏[1] 林久治[1] 

机构地区：[1]首都儿科研究所病理室

出　　处：《中华小儿外科杂志》1995年第5期268-270,共3页Chinese Journal of Pediatric Surgery

摘　　要：本文比较分析了１８例神经母细胞瘤的ＤＮＡ含量、Ｎ－ｍｙｃ基因扩增、临床分期、原发部位等因素与预后的关系。结果表明，有Ｎ－ｍｙｃ基因扩增的死亡率（７／１０）明显高于无扩增的（１／８）；ＤＮＡ、含量增高与肿瘤的恶性度成正比；临床分期与Ｎ－ｍｙｃ基因扩增情况相结合与病死率的关系极为密切。In this study,18 children with neuroblastoma were analysed on the relation among DNA content,N- myc gene amplification and the clinical staging.The results reveal:the mortality of patients with N-myc gene amplification(7/10)was higher than those without N-myc gene amplification(1/8);DNA content was related to malignancy of the tumor.combination of N-myc gene amplification and the clinical staging kept close link with the prognosis.

关 键 词：神经母细胞瘤 N-myc基因扩增 DNA 儿童 

分 类 号：R730.264[医药卫生—肿瘤]