食管癌贲门癌病人围术期的血清肌酸激酶及其同功酶MB  

Perioperative Changes of Serum Total CK and CK-MB in Patients with Carcinoma of Esophagus and Cardia of the Stomach

作　　者：孟毅[1] 刘锟[1] 王云杰[1] 张凡[1] 

机构地区：[1]第四军医大学唐都医院胸外科

出　　处：《中华胸心血管外科杂志》1995年第5期290-291,共2页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：采用荧光分光光度法和离子交换柱层析法分别测定38例食管癌、贲门癌病人手术前后血清总肌酸激酶(CK)和同功酶CK—MB值,并与18例肺手术病人、20例正常人进行临床对照。结果提示(1)食管癌、贲门癌本身不引起血清CK及CK-MB变化;(2)食管胃吻合术后血清总CK升高,主要来源于胸壁损伤骨胳肌;(3)总CK对食管围术期急性心肌梗塞(AMI)诊断缺乏特异性;而CK—MB可作为围术期AMI诊断的特异性酶学指标。The perioperative total serum CK and CK-MB activities were determined in 38 patients with carcinoma of the esophagus and cardia of the stomach with fluorometric and cylinder layer chromatography. The data were compared with those obtained from 18 patients undergoing pulmonary operation and 20 normal subjects. The results suggest that: (1) carcinoma of the esophagus and cardia of the stomach could not induce variation of the total serum CK and CK-MB; (2) the elevation of the total serum CK after esophagogas-trostomy might probably be due to the trauma of the skeletal muscles of the chest wall;(3)the total serum CK is non-specific for the diagnosis of AMI in the perioperation period,but CK-MB might be considered as a specific enzyme criteria.

关 键 词：肌酸激酶 肌酸激酶同功酶 食管肿瘤 贲门肿瘤 

分 类 号：R735.104[医药卫生—肿瘤] R735.204[医药卫生—临床医学]