丁胺卡那霉素在兔眼玻璃体内的药代动力学研究  

A PHARMACOKINETICAL STUDY OF AMIKACIN INJECTED INTO VITREOUS CAVITY OF RABBIT EYES

作　　者：曾水清[1] 吕源淑[1] 胡椿枝[1] 张缨[1] 

机构地区：[1]同济医科大学附属协和医院眼科

出　　处：《中华眼底病杂志》1995年第1期28-30,共3页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金

摘　　要：用荧光偏振免疫法检测丁胺卡那霉素在家兔正常眼、玻璃体切除和眼内炎等６种模型眼玻璃体中的药物动力学。结果表明丁胺卡那霉素在眼内的代谢速率在血－眼屏障和玻璃体受损后加快。从药物动力学的观点，玻璃体切除术用于轻度眼内炎会使眼内药物半衰期缩短，在重度眼内炎则能延长药物在眼内的停留时间。丁胺卡那霉素在眼内的吸收、分布和消除为一级动力学过程。The pharmacokinetics of amikacin injected into vitreous cavity of 6 groups of rabbit model eyes including normal eyes and eyes with endophalmitis and undergoing vitrectomy,was in-vestigated by means of fluorescence polarization immunoassay。The studies demonstrated that the half-life of the intravitreal amikacin in eyes undergoing vitrectorny and eyes with endophthalmitis was obviously less than that in the healthy eyes,The results indicated that damage of the blood-ocu-lar barrier could increase clearance of the drug in vitreous。From the pharmacokinetical point of view the vitrectomy may be quite beneficial for severe endophthalmitis。The absorption,the distri-butinn and the eliminatinn of intravitreal amikacin revealed the first order kinetics。

关 键 词：丁胺卡那霉素 药代动力学 玻璃体 兔眼 免疫检测 

分 类 号：R776.403[医药卫生—眼科] R969.1[医药卫生—临床医学]