血小板激活因子在急性胰腺炎大鼠肠系膜微循环障碍中的作用  

The role of platelet activating factor in mesenterio-angial microcirculatory disturbance complicated withacute pancreatitis in rats.

作　　者：冀振华[1] 王本茂[1] 李少华[1] 唐岩[1] 丁廷楷[1] 马元桂[1] 

机构地区：[1]北京海军总医院肝胆外科,第二军医大学长海医院普外科,海军医学研究所航海医学研究室

出　　处：《中华医学杂志》1995年第3期139-140,共2页National Medical Journal of China

摘　　要：为了探讨急性胰腺炎早期发生休克的机理，寻找早期治疗急性胰腺炎的新途径。作者应用激光多普勒显微镜观察了急性胰腺炎大鼠肠系膜微循环的变化，并用血小板激活因子拮抗剂苦杏内酯Ｂ（ＢＮ５２０２１）进行治疗对比研究。将１８只ＳＤ大鼠分成胰腺炎组、治疗组及对照组。前两组动物用５％牛磺胆酸钠（１ｍｌ／ｋｇ）成功复制急性胰腺炎模型。治疗组在模型复制成功后５分钟和１８０分钟经颈静脉注射苦杏内酯Ｂ（１０ｍｇ／ｋｇ），其它两组以生理盐水代替注射，同时观察动物的存活时间。结果提示：急性胰腺炎的早期即有肠系膜微循环小动、静脉血流速度的明显减馒，小静脉的扩张。苦杏内酯Ｂ能有效抑制这些改变。治疗组动物平均存活时间较胰腺炎组延长近一倍。o study shock in early acute pancereatitis (AP) ,we observed the change of mesenterio-angial micreeir-culationin the rat with AP induced by sodium tauro-cholate infused into the pancreatic duct. Meanwhile,the effect of platelet activating factor (PAF) receptorantagonist BN52021 upon the animal with AP was alsoinvestigated. 18 Sprague-Dawlay rats were divided in-to three groups: pancreatrtis group pan + BN52021group and control group. pan + BN 52021 group wasinjected BN52021 (10mg/kg)intravenously 5 minutesand 180 minutes. after AP induction The other groupswere injected nomal sahne. We also studied the sur-vival times of rats. The resuhs showed slow mesenteri-o-angial small arteriolar and venular blcod flow velocityand dilated meseaterioangial small venular diameterduring the early phase of AP. An protective effect ofBN 52021 on mesenterio-angial microcirculation injuriesaccompanied by AP was confirmed Animals treatedwith BN 52021 survived 458. 3±9. 5 minutes whereasdeath occurred 243. 3± 2. 3 minutes after AP inductionin untreated rats (P<0. 01).

关 键 词：胰腺炎 微循环 血小板激活因子 动物实验 病理 

分 类 号：R576.02[医药卫生—消化系统]