血清白细胞介素2和可溶性白介素2受体含量在原发性肝癌患者治疗前后的变化及临床意义  

CHANGES IN SERUM IL-2 AND sIL-2R LEVELS IN PATIENTS WITH PRIMARY HEPATIC CARCIN0MA BEF0RE ANO AFTER TREATMENT AND THEIR CLINICAL SIGNIFICANCE

作　　者：王敏[1] 冯懿正[1] 周杏仁[1] 方宝山[1] 张翔龙 马志敏[1] 瞿国伟[1] 俞运彪[1] 

机构地区：[1]浙江医科大学附属第一医院肿瘤外科,浙江医科大学附属第一医院血液科

出　　处：《中华肿瘤杂志》1995年第1期33-35,共3页Chinese Journal of Oncology

摘　　要：作者对１９例原发性肝癌患者手术切除和经皮股动脉穿刺肝动脉栓塞治疗前后血清白细胞介素２（ＩＬ－２）和可溶性白介素２受体（ｓＩＬ－２Ｒ）含量，用双抗体夹心ＥＬＩＳＡ法进行测定。结果表明：治疗前原发性肝癌患者ＩＬ－２含量明显低于正常对照组，ｓＩＬ－２Ｒ表达明显高于正常对照组。治疗后ＩＬ－２明显回升，ｓＩＬ－２Ｒ则明显下降。研究结果提示：原发性肝癌患者治疗后ＩＬ－２和ｓＩＬ－２Ｒ的含量变化可能与本病的治疗、复发、预后有关。Abstract Serum IL-2 and sIL-2R levels were measured with sandwith ELISA assay before and aftersurgery or transarterial embolization in 19 cases of primary hepatic carcinoma.The results show thatpretreatment IL-2 levels of patients were significantly lower and slL-2R expression was higher thanthose of normal control.IL-2 levels of patient were increased and sIL-2R expression Was decreased af-ter treatment.The results suggest that the changes of IL-2 level and slL-2R expression may be closelyrelated to treatment,recurrence and prognosis of patients with primary hepatic carcinoma.

关 键 词：白细胞介素2 血液 受体 肝肿瘤 药物疗法 

分 类 号：R735.705[医药卫生—肿瘤] R979.5[医药卫生—临床医学]