顺铂、硫代硫酸钠双途径化疗治疗恶性胸腔积液  

INTRAPLEURAL DDP AND SYSTEMIC THIOSULFATE RESCUE IN THE TREATMENT OF MALIGNANT PLEURAL EFFUSION

作　　者：华新民[1] 卢卫平[1] 段贵新[1] 王启文[1] 刘建阳[1] 

机构地区：[1]吉林省肿瘤医院

出　　处：《中华肿瘤杂志》1995年第1期50-52,共3页Chinese Journal of Oncology

摘　　要：１２０例由组织学或／和细胞学诊断的恶性胸腔积液，经胸腔内灌注顺铂（ＤＤＰ）５００～１０００ｍｇ，静脉滴注硫代硫酸钠（ＳＴＳ）（第１天１６～３２ｇ，第２～３天８～１６ｇ）解救，即“双途径化疗”（ＴＲＣ），共计１６８个疗程。每位患者经１～４个疗程治疗，其中胸水及肺内癌灶同时消失（特效）６例，占５％；胸水完全消失（显效）８３例，占６９．２％；胸水消退过半在１个月内无须再次抽胸水（有效）１９例，占１５．８％；在１个月内须再次抽胸水（无效）１２例，占１０％；总有效率９０．０％，（１０８／１２０）。毒副反应：胃肠道反应Ⅲ度３２例，Ⅳ度１４例，占３８．３％；肾毒反应Ⅲ度６例，Ⅳ度２例，占６．７％；骨髓反应Ⅲ度８例，Ⅳ度４例，占１０％，其中２例死亡，余者经过治疗２～３周内恢复。缓解期１～３２个月，平均６．４个月。存活超过６个月者７４例，占６１．７％。与其它胸水治疗方法比较，该方法具有较突出的疗效。ne hundred twenty cases of malignant pleural effusion were treated by intrapleural administra-tion of large doses of DDP(500～1000mg)followed by iv infusion of sodium thiosulfate for 3 days.Each patient received 1～ 4cycles of treatment.Of 120 cases,89 had their effusion completely disap-peared and in 6 of them,it was accompanied by complete regression of tumors in the lung. Partial re-sponse was observed in 19 cases with an overall response rate of 90.0%. The median remission periedwas 6.4 month.

关 键 词：恶性胸腔积液 药物疗法 顺铂 硫代硫酸钠 肺肿瘤 

分 类 号：R734.205[医药卫生—肿瘤] R979.1[医药卫生—临床医学]