西咪替丁增强鼻咽癌患者细胞免疫功能的临床实验研究  

CELL-MEDIATED IMMUNE FUNCTION IN NPC PATIENTS TREATED WITH CIMETIDINE

作　　者：曾平耀[1] 肖健云[1] 雷衍凡[1] 章正[1] 

机构地区：[1]湖南医科大学第三附属医院肿瘤科,湖南医科大学附属湘雅医院耳鼻喉科

出　　处：《中华肿瘤杂志》1995年第3期223-225,共3页Chinese Journal of Oncology

摘　　要：作者用随机分组研究，观察了４３例无远处转移鼻咽癌患者经放射合并西咪替丁（ＣＭＤ）治疗和单纯放射治疗后的细胞免疫功能变化。结果表明，放射合并ＣＭＤ治疗后，外周血Ｔ淋巴细胞ＣＤ＿４增多，ＣＤ＿８减少，ＣＤ＿４／ＣＤ＿８比率升高，ＮＫ活性和ＩＬ－２产生水平都增高。单纯放疗后，ＮＫ活性和ＣＤ＿４细胞增加，其他无显著变化。放射合并ＣＭＤ治疗组的ＣＤ＿４／ＣＤ＿８比率、ＩＬ－２产生水平和ＮＫ活性的变化幅度都高于单纯放疗组。提示ＣＭＤ能调节鼻咽癌患者的细胞免疫功能，是一种有效的免疫调节剂。Abstract Cimetidine(CMD),an H2 receptor antagonist, was used in combination with radiation forthe treatment of patirnts with nasopharyngeal cancer(NPC).In patients treated with radiothera-py alone,there was an increase in the number of CD_4￣+ T cells and in NK cell activity. In pa-tients received combined treatment of radiation and CMD,in addition,there was a decrease inCD_8￣+ T cells with an increase in CD_4/CD_8 ratio and an increase in IL-2 production,The NK cellactivity was also stronger in the latter group.The results suggest that CMD helps restore cell-mediated immunity in NPC patients radiation treated.

关 键 词：西咪替丁 鼻咽肿瘤 细胞免疫 药物疗法 

分 类 号：R739.630.5[医药卫生—肿瘤] R975.6[医药卫生—临床医学]