醛氢叶酸、5－氟脲嘧啶、顺铂疗法治疗食管癌的增效作用  

CF/5-FU-DDP THEERAPY FOR ESOPHAGEAL CARCINOMA

作　　者：王瑞林 樊青霞[1] 王志良[1] 李苏宜[1] 

机构地区：[1]河南医科大学第一附属医院

出　　处：《中华肿瘤杂志》1995年第5期362-364,共3页Chinese Journal of Oncology

摘　　要：从１９９２年３月至１９９４年５月，作者采用醛氢叶酸（ＣＦ）、５－氟脲嘧啶（５－Ｆｕ）、顺铂（ＤＤＰ）疗法（Ａ组）及５－Ｆｕ－ＤＤＰ联合化疗（Ｂ组）治疗食管癌１０５例。全部病例均经病理学或细胞学证实，并有可测量的临床学及Ｘ线观察指标。结果显示：Ａ组４０例，有效率８０％；Ｂ组６５例，有效率６０％。两组疗效比较，差异有极显著性意义（Ｐ＜０．０１）。因Ａ、Ｂ两组化疗后均即行放疗或手术，故中数生存时间有待长期随访。Ａ组恶心、呕吐、心脏毒性和白细胞减少的发生率高于Ｂ组；Ａ组的口腔粘膜炎、腹泻、腹痛和色素沉着为Ｂ组所没有。但所有毒性均可耐受。结果表明，ＣＦ／５－Ｆｕ－ＤＤＦ方案的疗效优于５－Ｆｕ－ＤＤＰ方案。该方案是目前药物治疗食管癌疗效较好的方法之一。AbstractFrom March 1992 to May 1994,105 patients with esophageal carcinoma patients were treat-ed with CF/5-Fu-DDP(group A,n=40)or 5-Fu-DDP(group B,n=65)protocol.The responserate(CR +PR)was 80%in group A and 60%in group B.P<0.01)Induction chemotherapywas followed by surgery or radiation therapy.The incidence of nausea,vomiting,cardiotoxicityand leukopenina was higher in group A than in group B.Buccal mucositis,diarrhea,abdomenalpain and skin pigmentatin were noted only in group A.However,the toxic effects were tolerable.The results suggest that the CF/5-Fu-DDP regimen is more effective than 5-Fu-DDP regimen andmay be one of the best chemotherapy regimens for the treatment of esophageal carcinoma.

关 键 词：食管肿瘤 药物疗法 醛氢叶酸 氟脲嘧啶 顺铂 

分 类 号：R735.105[医药卫生—肿瘤] R979.1[医药卫生—临床医学]