脊索瘤的免疫组织化学研究在诊断和鉴别诊断中的意义  

SIGNIFICANCE OF IMMUNOHISTOCHEMICAL STUDY IN THE DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF CHORDOMA

作　　者：徐亚利[1] 徐克纾 纪萍[1] 初珂[1] 项峰刚 

机构地区：[1]青岛市市立医院

出　　处：《中华肿瘤杂志》1995年第6期435-437,共3页Chinese Journal of Oncology

摘　　要：作者运用免疫组织化学方法对７例脊索瘤、６例软骨肉瘤和３例大肠粘液腺癌进行上皮源性、神经源性、间叶源性以及肌源性和组织细胞源性抗体联合标记。结果脊索瘤显示多种标记物阳性：Ｃｙｔｏ－Ｋ６／７，ＥＭＡ７／７，ＣＥＡ６／７，Ｖｉｍ７／７，Ｓ－１００蛋白７／７，ＧＦＡＰ０／７，Ｄｅｓ０／７，α－ＡＴ７／７，Ｌｙｓｏ４／７。提示脊索瘤具有多种组织分化潜能，与胚胎的脊索组织免疫组化反应相似。６例软骨肉瘤的上皮性标记物均阴性，Ｖｉｍ和Ｓ－１００蛋白１００％阳性；３例粘液腺癌除上皮性标记物阳性外，其它均为阴性。以上结果为脊索瘤的病理诊断，特别是与软骨肉瘤和粘液腺癌的鉴别诊断提供了有力佐证。Abstract Seven cases of chordoma were studied immunohisto-chemically with antibodies directed to epithelium,nerve,mesenchyme,muscle and histiocyte. Six cases of chondrosarcoma and three cases of mucinous carcinoma of colonwere studied as control. The results showed that the chordomas were positiive for cyto-K 6/7, EMA 7/7, CEA6/7, Vim 7/7,S-100 7/7, α-AT 7/7,Lyso 4/7,while negative for GFAP and Des in all 7 cases indicating thatchordoma,just like notochord,had the potentiality of multidirectional differentiation,In contrast,none of thechondrosarcomas was positive for cyto-K,EMA or CEA,but positive for Vim and S-100 in 6 cases. Three cases ofcolon mucinous carcinoma were positive for epithelial antibodies,but none reacted with other antibodies. Thus,immunohistochemical studies are of help in the diagnosis and differential diagnosis of chordoma.

关 键 词：脊索瘤 免疫组织化学 诊断 鉴别诊断 

分 类 号：R730.269[医药卫生—肿瘤]