p53过表达和nm23低表达与胃癌淋巴结转移关系的探讨  

GASTRIC CANCER WITH P53 OVERXPRESSION AND nm23 LOW-EXPRESSION HAS HIGH POTENTIAL FOR LYMPH NODE METASTASIS

作　　者：张声[1] 叶圣华[1] 林华[1] 

机构地区：[1]福建医学院附属第一医院病理科

出　　处：《中华肿瘤杂志》1995年第6期418-421,共4页Chinese Journal of Oncology

摘　　要：应用Ｓ－Ｐ免疫组化方法研究Ｐ５３和ｎｍ２３表达变化与胃癌生物学行及淋巴结转移的关系。发现Ｐ５３阳性染色率为４９％，Ｐ５３过表达与肿瘤浸润深度及癌细胞增殖活性呈正相关（Ｐｅａｒｓｏｎ列联系数分别为Ｐ＝０．３２和Ｐ＝０．３５，Ｐ＜０．０５），Ｐ５３阳性肿瘤的淋巴结转移率（９３％）明显高于Ｐ５３阴性的肿瘤（６０％，Ｐ＜０．０５）。同时发现ｎｍ２３低表达与胃癌侵袭程度显著相关（Ｐｅａｒｓｏｎ列联系数Ｐ＝０．２８，Ｐ＜０．０５）。ｎｍ２３低表达者淋巴结转移率（９３％）比正常表达者高（４９％，Ｐ＜０．０５）。Ｐ５３过表达和ｎｍ２３低表达在胃癌淋巴结转移中的关系为独立的联合作用。提示Ｐ５３过表达和ｎｍ２３低表达在胃癌淋巴结转移和肿瘤浸润及增殖中起重要作用。AbstractBy using SP immunohistochemical methods,the correlation of the expression of P53 and nm23with the biologic behavior and lymph node metastasis in gastric carcinomas was studied. Abnor-malities of P53 expression were found in 49% of the 88 primary gastric carcinomas. A significantcorrelation was found between p53 overexpression and the depth of invasion and the proliferativeactivities(Pearson Contingency Coefficient p=0. 32 and 0.35,P<0. 05,respectively).Themetastatic rate of tumours stained positively for p53 (93%)were higher than in those with nega-tive P53 staining(60%,P<0.05)Meanwhile, a significant correlation of low expression ofnm23 with the depth of cancer invasion was found(Pearson Contingency Coefficient p=0.28,P<0.05).nm23 low-expressive tumours were associated with a higher incidence of metastasis tolymph nodes(93%)than were nm23-normal expressive(49%,P<0.05).The contributions ofP53 overexpression and nm23 low-expression to the lymph nodal metastasis were the independentjoint action. It is suggested that p53 overexpression and nm23 low-expression might play signifi-cant role in lymph node metastasis and invasion and proliferation in the primary gastric carcino-mas.

关 键 词：胃肿瘤 淋巴结转移 P53基因 NM23基因 

分 类 号：R735.202[医药卫生—肿瘤]