参仙升脉液对离体大鼠心脏工作模型血液动力学的影响  

The Effect of Shenxian Shengmai Liquid on the Hemodynamics of Isolated Work Model of Rat Heart

作　　者：施雪筠[1] 龙致贤[1] 刘爱鸾 杨淑芳[1] 马金莲[1] 王鼎中 

机构地区：[1]北京中医药大学,美国纽约州罗切斯特尔大学医学院

出　　处：《中药新药与临床药理》1995年第2期20-21,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：参仙升脉液是主治病态窦房结综合征的中药复方制剂。经临床近３００例患者验证结果，总有效率达９０％左右，平均每ｍｉｎ提高心率１０－１５次。本文为研究该药的作用机理，采用离体大鼠心脏灌注工作模型，观察经超滤后的参仙升脉液对血流动力学各指标的影响。结果提示该药有降低冠脉血管阻力（２６．９±２４％），增加冠脉流量（３４．６±３．９％）和提高心率（２６．６±１．４％）的作用。用药后主动脉流量减少，对心输出量及舒张压无明显影响。这可能与该药引起心输出量的再分配有关。Shenxian Sliengniai Liquid(SSL) is a herbal preparation for the treatment of sick sinussyndrome(SSS), which is manufactured by ultrafiltration. Through the clinical observation of nearly 300cases of SSS, its total effective rate was 90.00% and the heart rate was increased byl 0 to 15 beats per minutein average, For the study of its therapeutic mechanism, the isolated work model of rat heart was employedand its effect on various criteria of hemodynamics was observed. The results showed that the coronaryvascular resistance was significantly reduced (26.9 ± 2.4%), the coronary blood flow was increased (34.6 ±3.9%and the heart rate was also increased(28.6 ± 4. 1%).The blood low in the aorta was reduced,while thecardiac output and the diastolic blood pressure were not affected. It is suggested that the therapeulic mecha-nism of SST is possibly related to the redistribution of the cardiac output.

关 键 词：参仙升脉液 药理学 动物模型 血液动力学 

分 类 号：R285.5[医药卫生—中药学]