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作 者:冯学胜[1] 汤钊猷[1] 薛琼[1] 郑仲承[1] 戈凯[1] 刘新垣[1]
机构地区:[1]上海医科大学肝癌研究所,中国科学院上海生物化学研究所
出 处:《肿瘤》1995年第5期373-375,共3页Tumor
基 金:中华医学会基金;中国863-102-1605基金
摘 要:体外细胞毒实验测试发现重组人肿瘤坏死因子alpha(rHTNF_α)对体外培养的人原发性肝癌细胞系SMMC7721和BEL7404有较强的细胞毒作用,这种作用具有剂量依赖性。形态学研究表明,受rHTNF作用的肝癌细胞呈现调亡细胞的特征,即胞核固缩,部分成片状,细胞变小,聚集成团落,在体外实验的基础上,对SMMC-7721,细胞的裸鼠人肝癌模型进行实验治疗,结果提示:瘤内单独注射rHTNF(500U/只,qdx3),即有一定抗瘤效应,合用DDP后效果明显,这些结果预示rHTNF在肝癌治疗中的潜在意义。In vitro antitumor effects of recombinant human tumor necrosis factor alpha(rHTNF_α) on human hepatocellular carcinoma(HCC) cell line, SMMC-7721 and BEL-7404, were observed by using MTT cytotoxieity assay,which was dose-dependent. Morphological study by phase contrast and electron microscope showed that a programmed cell death(or apoptosis) was induced by rHTNF_α in SMMC-7721.An in vivo antitumor activity of rHTNF_α alone or in combination with cisplatin(DDP, one widely used chemotherapeutic agent for HCC)was studied in a nude mouse model with SMMC-7721 cells subcutaneously transplanted. The results showed that rHTNF_α inhibited the tumor growth when used intralesionally, especially in combination with DDP.The above data suggest that rHTNF_α has a potential role in treatment of HCC.
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