恶性滋养细胞肿瘤中表皮生长因子的表达与胎盘激素含量的关系  

A study on relationship between expression or epidermal growth factor (EGF) and contents or placental hormones in malignant trophoblastic neoplasms

作　　者：熊永炎[1] 唐志佼[1] 曾俊[1] 邢寿富[1] 

机构地区：[1]湖北医科大学病理学教研室

出　　处：《肿瘤防治研究》1995年第3期135-137,共3页Cancer Research on Prevention and Treatment

基　　金：省教委资助

摘　　要：应用免疫组化方法，采用抗表皮生长因子（ＥＧＦ）、绒毛膜促性腺激素（ｈＣＧ）、胎盘泌乳素（ｈＰＬ）及妊娠特异性β＿１糖蛋白（ＳＰ＿１）抗体，分别检测９１例恶性滋养细胞肿瘤（侵蚀性葡萄胎２９例，绒毛膜癌２９例，转移性侵蚀性葡萄胎１２例，转移性绒毛膜癌２１例）中ＥＧＦ和三种胎盘激素的含量。结果表明，不同肿瘤性滋养细胞中ＥＧＦ的表达以合体滋养细胞（ＳＴ）最强，中间型滋养细胞（ＩＴ）居中，细胞滋养细胞（ＣＴ）最弱。ＥＧＦ在侵蚀性葡萄胎中的表达明显高于绒毛膜癌（Ｐ＜０．１），而在上述二种恶性滋养细胞肿瘤的原发瘤和转移瘤中的表达无差异性（Ｐ＞０．１）。ＥＧＦ表达越强，ｈＰＬ和ＳＰ＿１的含量越高。由于ＥＧＦ在侵蚀性葡萄胎中的表达明显高于绒毛膜癌，所以ｈＰＬ和ＳＰ＿１的含量在前者显著高于后者（Ｐ＜０．０１）。根据本文和我们较早的观察，我们认为ＥＧＦ对恶性滋养细胞肿瘤的分化、增生及胎盘激素的分泌均具有一定促进作用。The expression of EGF and contents of three placental hormones in 91 malignant trophoblastic neoplasms(including 29 invasive moles, 12 metastatic invasive moles,29 choriocarcinomas,21 metastatic choriocarcinomas)were studied immunohistcohemically using a panel of antibodies against EGF,hCG,hPL and SP1.The results indicatsd that the expression of EGF was most intensive in neoplasticsyncytiotrophoblast(ST),middle in neoplastic intermediate trophoblast(IT),most faint in neoplastic cytotrophoblast(CT),There was a relationship between expresson of EGF and secretion of placental hormones in malignant trophoblastic tumors.The expression of EGF was more intensive, the secretion of hPL and SP1 were more marked.Because expression of EGF in invasive mole was more intensive than one in cboriocarcinoma(P<0.1),so contents of hPL and SP1 in the former were more high than one in the latter(P<0.01).According to our present and earlier studies, we consideredthat EGF played a promotive role for differentiation, proliferation and secretion of placental hormonesin malignant trophoblastic neoplasms. Finally, some question abaut expression of EGF and secretionof hCG was discussed.

关 键 词：滋养细胞瘤 癌 表皮生长因子 胎盘激素类 

分 类 号：R737.33[医药卫生—肿瘤]