食管癌间质中巨噬细胞浸润的意义  

Significance of macrophage infiltration in the stroma of esophageal squamous cell carcinoma

作　　者：马玉祥[1] 冼美生[1] 

机构地区：[1]河北医学院附属第四医院癌检诊中心

出　　处：《肿瘤防治研究》1995年第5期276-277,共2页Cancer Research on Prevention and Treatment

摘　　要：本文以单克隆抗体ＣＤ（６８）用ＡＢＣ法，对２７例食管鳞癌间质中浸润巨噬细胞的分布进行定量观察发现：巨噬细胞主要浸润于癌周间质内，并与淋巴样细胞混杂存在，癌组织侵犯深，前缘退变程度轻和有局部淋巴结转移者，巨噬细胞浸润数量少，反之则较多。提示癌间质内巨噬细胞浸润是宿主抵抗肿瘤侵袭性生长的重要免疫形态学表现。This paper presents a quantitative study of macrophage infiltration in the stroma of 27 cases of esophageal squamous cell carcinoma using ABC method with monoclonal antibody against macrophage. Our study revealed:Macrophage infiltrates mostly at the peripheral portion of cancer stroma, and often mixed with lymphoid cells. The deeper invasion, milder degenorative change in peripheral portion of cancer and with positive lymphnode metastasis, the weaker macrophage infiltration appears in the stroma around the carcinoma. These data suggested that the macrophage infiltration is an important expression of host immunologic defense against cancer.

关 键 词：食管肿瘤 鳞癌 巨噬细胞 免疫形态学 

分 类 号：R735.1[医药卫生—肿瘤]