细胞色素P450 2E_1基因多型性在酒精性肝病及肝癌发病中的作用  

ROLE OF GENETIC POLYMORPHISMS OF CYTOCHROME P450 2E_1 IN PATHOGENESIS OF CHRONIC ALCOHOLIC LIVER DISEASES AND PRIMARY LIVER CANCER

作　　者：李昌平[1] 邹义君[1] 陈光东[1] 刘厚钰[2] 周康[2] 付志君 

机构地区：[1]泸州医学院附属医院消化内科,646000 [2]上海医科大学中山医院

出　　处：《泸州医学院学报》1995年第4期243-246,共4页Journal of Luzhou Medical College

摘　　要：为研究细胞色素P4502E1基因（2E1）不同类型在酒精性肝病和肝癌发病中的作用，用PCR法及内切酶消化将2E1基因分为A型、B型、C型．结果显示26例正常人和70例慢性非酒精性肝病和肝硬化的2E1基因类型均以A型为主（分别为65．4％和62．8％），二者相比，差别无显著意义（P＞0．05）．45例慢性酒精性肝病以B型为主（91％）．与正常人及非酒精性肝病和肝硬化相比，B型明显升高（P＜0．01）．提示不同类型2E1基因在酒精性肝病、肝硬化中的作用不同，C2基因升高，C1基因降低在酒精性肝病中起重要作用．对40例原发性肝癌2E1基因分析发现，C2基因发生率在酒精有关的肝癌中明显高于与酒精无关的肝癌（P＜0．01），提示C2基因与酒精致癌关系密切．To investigate the roles of various cytochrome P45O 2El in pathogenesis of chronicalcoholic liver diseases and primary liver cancer, gene 2E1 was divided into 3 types: i. e. type A whichis homozygous for the C, gene; type B which is heterozygous fo C1 and C2 gene, and type C which ishomozygous for C2 gene. The results showed that the incidences of type A B C of 2E1 were 65. 4%34. 6% and 0% respectively in 26 normal controls and 62. 8% 35. 7% and 1. 4% in 70 patients withnon-alcolholic liver diseases. there was no significant difference between the two groups. The incidiences of type A B C (4. 4 % 91 %and 4. 4 % ) in 45 patients with alcoholic liver diseases were signifi-cantly diferent (P<0. 01) from those in normal control and in patients with non-alcoholic liver dis-eases. the results suggested that Ct gene may play an important role in the development of alcoholic liv-er diseaes. Results of 2El gene analysis in liver cancers with various etiology indicated that incidenceof C: gene in alcoholrelated liver cancer was higher than that in non-alcoho-related liver cancer, whichsuggested that C2 gene may also play som roles in carcinogenesis of ethanol.

关 键 词：酒精性肝疾病 肝脏肿瘤 细胞色素P450 基因分型 

分 类 号：R575.202[医药卫生—消化系统] R735.702[医药卫生—内科学]