肝细胞癌患者肝组织中丙型肝炎病毒抗原的定位研究  

LOCALIZATION OF HEPATITIS C VIRUS ANTIGEN IN LIVER TISSUES OF PATIENTS WITH HEPATOCLLULAR CARCINOMA

作　　者：崔晓红[1] 戚中田[1] 潘卫 宋艳斌 李琳 郝连杰 王一[1] 张秀忠[1] 丛文铭[1] 吴孟超[1] 

机构地区：[1]上海第二军医大学东方肝胆外科研究所,上海第二军医大学微生物学教研室,武汉同济医科大学同济医院临床免疫室

出　　处：《肝脏病杂志》1995年第1期13-14,共2页

摘　　要：用过氧化物酶与抗过氧化物酶（ＰＡＰ）法检测了７３例肝细胞癌（ＨＣＣ）患者肝组织中的丙型肝炎病毒抗原（ＨＣＶＡｇ）和ＨＢｓＡｇ及ＨＢｃＡｇ。结果显示，ＨＣＶＡｇ、ＨＢｓＡｇ和ＨＢｃＡｇ的检出率分别为２８．８％、７５．３％和２６．０％；ＨＣＶＡｇ阳性的肝细胞多呈散在型分布，ＨＣＶ染色颗粒既可见于细胞浆也可见于细胞核；ＨＣＶＡｇ的检出与ＨＢＶ的感染状态无显著相关。提示，ＨＣＶ可在ＨＣＣ患者的肝细胞中表达，ＨＣＶ感染可能在我国ＨＣＣ的发生中起一定的病原学作用。Liver samples from 73 patients with hepatocellular carcinoma(HCC)were detected for hepatitis C virus antigen (HCVAg) HBsAgand HBcAgby peroxidase-antiperoxidase(PAP)method The positive rates of HCVAg HBsAgand HBcAgwere 28. 8% 75.3%and 26.0%respectively HCVAgpositive hepatocytes were distributed sporadically,and HCVAggranules were found in cytoplasm and nuclei of the hepatocytes No correlation was found between HCVAgand HBV infectious status。 These results suggested that HCV infection may play an etiological role in the development of HCC in China。

关 键 词：肝细胞癌 丙型肝炎病毒 抗原 定位 

分 类 号：R735.702[医药卫生—肿瘤] R373.21[医药卫生—临床医学]