胃腺套管的病理形态及免疫组织化学观察  

Pathomorphological and immunohistochemical studies of gastric gland casing

作　　者：王仰坤[1] 马乃绪[1] 王恩升[1] 黄如川[1] 王志红 

机构地区：[1]解放军150医院,解放军91医院

出　　处：《诊断病理学杂志》1995年第1期26-28,共3页Chinese Journal of Diagnostic Pathology

摘　　要：本文对３８８例胃粘膜活检标本进行了形态学观察，发现有３４．８％的病例呈现腺内套管，以胃息肉、萎缩性胃炎和管状腺癌为多见。根据套管上皮细胞的增生程度分为不伴异型性增生套管和异型增生套管两种，Ｐ２１蛋白在不伴异型性增生套管中均为阴性表达，异型增生套管上皮细胞中用性表达４７．９％；ＣＥＡ（癌胚抗原）在不伴异型性增生套管上皮细胞中阳性表达为１３．３％，异型增生套管上皮细胞中阳性表达高达６８．８％。结果提示不伴异型性增生套管是一种良性增生性病变，异型增生套管则是重要的癌前期病变。Gastric mucosa biopsies obtained from 388 cases were studied pathologically. It was found that 34. 8% of the cases had gastric gland casings often seen in cases with gastric polyp,chronic atrophic gastritis and tubular adenocarcinoma. According to the degree of epithelial cell hyperplasia of glandular casing, the gastric gland casing can be divided into non-dysplastic and dysplastic types. All the non-dysplastic type of gastric gland casings had negative P21 protein expression, and the positive expression on epithelial cells of dysplastic type was 47. 9%. The positive expression of carcinoembryonic antigen (CEA) on the epithelial cells of non-dysplastic type was 13. 3% and on the cells of dysplastic type, as high as 68. 8%. The results suggest that non- dysplastic type of gastric gland casing be a benign hyperplastic lesion, while the dysplastic type be a pre-cancerous lesion.

关 键 词：胃腺套管 异型增生 免疫组化 胃肿瘤 癌前病变 

分 类 号：R735.202[医药卫生—肿瘤] R573.02[医药卫生—临床医学]