高分化鳞癌与假癌性增生的免疫组织化学鉴别研究  

Immunohistochemical study on differential diagnosis between well-differentiated squamous cell carcinoma and pseudocarcinomatous hyperplasia

作　　者：冼美生[1] 于颖彦[1] 马玉祥[1] 李英敏 

机构地区：[1]河北医学院病理学教研室

出　　处：《诊断病理学杂志》1995年第1期35-37,共3页Chinese Journal of Diagnostic Pathology

摘　　要：高分化鳞癌（ＷＤＳＣ）与假癌性增生（ＰＣＨ）的组织形态学鉴别迄今仍是外科病理学棘手难题之一。本文以抗人、抗牛角蛋白多克隆抗体，双ＰＡＰ法观察、分析其角蛋白抗原表达。结果表明：ＷＤＳＣ组２０例中１７例（８５％）呈不规则表型，２例基本阴性，仅１例规律型。ＰＣＨ组１０例中７例（７０％）呈规律性表型，３例呈弱杂乱不规则表型。两组角蛋白表型统计学处理差异显著（Ｐ＜０．０１）。本文认为仔细分析组织形态特征的同时，应用角蛋白抗体免疫组织化学观察对疑难的ＷＤＳＣ与ＰＣＨ的鉴别诊断有一定实际意义。Differential diagnosis between well -differentiated squamous cell carcinoma (WDSC) and pseudocarcinomatous hyperplasia (PCH) is still one of the difficult problems in surgical pathology. We observed the keratin expressions by using double PAP method with anti - human and anti -bovine keratin polyclonal antibodies. The results showed that three patterns of keratin expression were observed. Seventeen (85%) out of 20 cases of histologically diagnosed WDSC showed irregular pattern, 2 cases were almost of no expression and only one case showed regular pattern. On the contrary, in 10 cases of PCH, 7 were of regular and 3 of weak irregular pattern. The results indicate that the keratin expression was remarkably different statistically in this two groups (P<0. 01). This study suggests that besides detailed histologic examinations, immunohistochemical method by using keratin antibodies be beneficial for the differential diagnosis in some difficult cases between WDSC and PCH.

关 键 词：高分化鳞癌 假癌性增生 免疫组化 鉴别诊断 

分 类 号：R730.43[医药卫生—肿瘤]