大鼠实验性胃溃疡自愈期间胰岛IAPP－IR细胞与Ins－IR细胞的形态计量研究  

MORPHOMETRIC STUDY ON ISLET IAPP-AND INS-IR CELLS DURING DXPERIMENTAL GASTRIC ULCER IN RATS

作　　者：李占淳[1] 石爱荣[1] 

机构地区：[1]北京医科大学组织学与胚胎学系

出　　处：《北京医科大学学报》1995年第5期333-335,346,I028,共4页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：用免疫组化ＰＡＰ法，显示胰岛ＩＡＰ－和Ｉｎｓ－ＩＲ细胞，观察大鼠实验性胃溃疡自愈期间胰岛ＩＡＰＰ－和Ｉｎｓ－ＩＲ细胞的形态计量变化。溃疡第４～１４天，胰岛ＩＡＰＰ－ＩＲ细胞的面数密度明显升高，第２１和２８天基本恢复正常；而Ｉｎｓ－ＩＲ细胞的面数密度，在溃疡第６和１０天显著下降，第２８天基本恢复正常。提示胰岛Ｂ细胞内ＩＡＰＰ和Ｉｎｓ以不同的方式参与了溃疡自愈过程的调节。he changes of islet IAPP-and Ins-IR cells during experimental gastric ulcer in rats were observed by imniuno-histocliemical PAP method, and analysed by morphornetry.It was shown that the numerical density on areas ofislet IAPP-IR cells increased significantly during 4-14 days after inducing ulcer; then returned gradurally to normallevel on the 21th and 28th day. However,the numerical density on areas of islet Ins-IR cells decreased obviouslyon the 6th and 10th day,and was back to normal level on the 28th day.These results indicated that IAPP and In-scoexisting in islet B-eells changed contrary each other during ulcer healing.The present work suggests that IAPP andIns may participate in the regulation of the healing process of gastric ulcer.

关 键 词：大鼠 胃溃疡 自愈 胰岛 细胞学 

分 类 号：R573.1[医药卫生—消化系统]