胃癌组织中肥大细胞与C－erbB－2癌基因蛋白  

Mast cell and C-erbB-2 oncoproteins in the tissues or gastric cacinoma

作　　者：张友元[1] 张子俊 肖和平 刘树棠 邢寿富[1] 

机构地区：[1]黄石市第三医院病理科,湖北医科大学病理学教研室

出　　处：《肿瘤防治研究》1995年第6期359-360,F004,T001,共4页Cancer Research on Prevention and Treatment

摘　　要：用俾士麦棕法和免疫组织化学方法检测了５７例胃癌组织中肥大细胞（ＭＣ）和Ｃ－ｅｒｂＢ－２癌基因蛋白。结果表明：（１）ＭＣ计数与胃癌的分化程度和转移有关，高、中分化腺癌高于低分化腺癌和未分化癌（Ｐ＜０．０５），无转移者高于有转移者（Ｐ＜０．０５）；（２）Ｃ－ｅｒｂＢ－２癌基因蛋白阳性表达与胃癌的分化程度和转移无关（Ｐ＞０．０５）；（３）Ｃ－ｅｒｂＢ－２癌基因蛋白阳性表达与ＭＣ计数有关，ＭＣ高计组，Ｃ－ｅｒｂＢ２癌基因蛋白阳性表达低于ＭＣ低计组（Ｐ＜０．０５）。Bismark brown staining method and immunohistochemical method were used respectively for the observation of mast -cell (MC) and C-erbB-2 oncoproteins in 57 cases of gastric carcinoma. The results showed that:(1)MC counts were related to the differentiation and metastasis of gastric cancer, in the high and moderate differentiation tumors, MC counts were higher than in the low and undifferentiated ones (P<0. 05) and in the metastatictumours they were lower than in the nonmetastatic ones (P<0. 05). (2) C-erbB-2 oncoproteins were not related to the differentiation and metastasis of gastric cancer (P>0. 05).(3) The positive expression of C-erbB-2 oncoproteins were related to MC counts of gastric cancer, high MC count groups were inferior to low MC ones (P<0. 05).

关 键 词：胃肿瘤 肥大细胞 癌基因 免疫组织化学 

分 类 号：R735.202[医药卫生—肿瘤]