环氧乙烷的遗传毒性研究Ⅳ．小鼠骨髓细胞染色体畸变亚急性试验  

STUDY ON THE GENOTOXICITY OF ETHYLENE OXIDE IV THESUBACUTE TEST OF CHROMOSOMAL ABERRATION OF BONEMARROW CELLS IN MICE

作　　者：陆静芬[1] 张龄[1] 夏国兴[1] 钟坤[1] 

机构地区：[1]上海职工医学院,上海市卫生学校

出　　处：《癌变．畸变．突变》1995年第2期101-103,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金

摘　　要：以４组小鼠各１０只为一组，分别给予ＥｔＯ吸入剂量为５４，１８０，５１Ｏｍｇ／ｍ３２ｈｒ／ｄ连续５天，观察了ＥｔＯ对小鼠骨髓细胞染色体畸变的畸变率，发现总畸变率分别为０．５，１．２，３．２，７．Ｏ％，高浓度（５４０ｍｇ／ｍ３）、中等浓度（１８０ｍｇ／ｍ３）二组与对照组比较有统计显著性差异；而低浓度（５４ｍｇ／ｍ３）组与对照组比较无显著差异。结果表明ＥｔＯ使小鼠骨髓细胞分裂中的染色体畸变，主要为裂隙、断裂及断片，且随着浓度的增加而加剧。The subacute test of chromosornal aberration of bone marrow cells in mice inhaled ethylene oxide were studied.We found the significant differences of chromosomel aberrationfrequencies between the high concentration(540mg/m3)group,middle concentration(180mg/m3)group and control group(P<0. 0l).But there are no significant differences betweenthe lower concentration(54mg/m3)group and control group(P>0.05).The results showedthat ethylene oxide may induce chromosomal aberration of bone marrow cells in mice and thechromosomal aberration frequencies were increased with the concentration of ethylene oxide.

关 键 词：环氧乙烷 遗传毒性 染色体畸变 工业毒理 

分 类 号：R994.3[医药卫生—毒理学]