环氧乙烷遗传毒性的研究V．亚慢性吸入环氧乙烷的小鼠骨髓细胞染色体结构畸变试验  

STUDY ON THE GENOT0XICITY OF ETHYLENE OXIDEV.CHROMOSOME ABERRATION OF MARROW CELLS OF MICE AFTER SUBCHRONIC INHALATION

作　　者：夏国兴[1] 张龄[1] 陆静芬[1] 钟坤[1] 方芳 

机构地区：[1]上海市卫生学校,上海职工医学院

出　　处：《癌变．畸变．突变》1995年第3期155-157,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金

摘　　要：本文观察环氧乙烷（ＥＴＯ）亚慢性吸入染毒小鼠（５４ｍｇ／ｍ３，３６Ｏｍｇ／ｍ３，２ｈ／ｄａｙ，６ｄ／Ｗｋ，／１４ｗｅｅｋ）骨髓细胞染色体结构畸变率显著高于正常对照组（４．２％Ｐ＜０．０１），５４ｍｇ／ｍ３染毒组未见显著性差异。此外，发现两组染毒小鼠骨髓细胞分裂相明显少于正常对照组，３６０ｍｇ／ｍ３浓度组细胞分裂抑制效应大于５４ｍｇ／ｍ３浓度组，细胞分裂受抑制的机理尚待探讨。The chromosome aberrations of bone marrow cells in mice with subchronic inhala- tion of ethylene oxide were observed.Significant difference was found between the highestconcentration( 360 mg/m3)and control group on 2h/6day/14wk, but not in the 54 mg/m3group. On the other hand,the depressing effects of bone marrow cells division due to ethy- lene oxide,especially in the highest 360mg/m3 concentration group,was noticed also.

关 键 词：环氧乙烷 染色体结构畸变 骨髓细胞 工业毒理 

分 类 号：R994.3[医药卫生—毒理学]