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作 者:林凤茹[1] 李玉秀[1] 姚尔固[1] 徐世荣[1] 卫俊萍[1] 刘素云[1] 张晋霞[1] 王云 朱爱英[1]
机构地区:[1]河北医学院附属第二医院
出 处:《白血病》1995年第1期16-19,共4页
摘 要:分析了5种血清急相蛋白在22例初治急性白血病患者的临床意义。结果表明:治疗前白血病患者C反应蛋白(CRP),α_1-酸性糖蛋白(α_1-AG)明显高于正常(P<0.001)。α_1-抗胰蛋白酶(α_1-AT)、α_2-巨球蛋白(α_2-M)及β_2-微球蛋白(β_2-MG)与正常对照无差异(P>0.05)。白血病患者CRP又明显高于非恶性血液病患者(P<0.01)。完全缓解后CRP、α_1-AG、α_1-AT、β_2-MG下降至正常,明显低于未缓解者。急相蛋白在未缓解者仍持续高于正常。α_1-AG与α_1-AT的水平与外周血白细胞数相关。认为血清急相蛋白特别是CRP其次为α_1-AG和α_1AT对鉴别恶性与良性血液病有一定意义,动态观察能反映白血病细胞负荷及预测其治疗转归。We analysed the clinical signmcance of five kinds of serum acute phase proteins in 22 cases ofnewly diagnosed acute leukemia。 The results showed that before treatment,the C-reactiveprotein(CRP) and α_1-acid glycoprotein(α_1-AG )in leukemic patients were significantly higherthan that of controls(P< 0. 001).There were no stutistical difference in α _2-macroglobulin( α_2-M),α_1-antitrypsin(α_1-AT)and β_2-microglobulin(β_2-MG ) ( P>0. 05 ).The CRP of leukemiccases was also significantly higher than that of nonmalignant blood disease cases(P<0. 01).After complete remission,CRP,α_1-AG ,α_1-AT and β_2-MG were decreased to normal,obviouslylower than those of non-responders. The acute phase proteins in non-remission cases werepersistently higher than those in responders.The levels of α_1-AG and α_1-AT correlated with theperipheral white blood cell count. We consider that acute phase proteins, particularly CRP,inthe next place the α_1-AG and α_1-AT might be of value in differentiating malignant and non-malignant blood disorders,and their kinetic studies might reflect the leukemic cell mass and couldpredict the therapeutic outcomes.
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