恶性淋巴瘤AgNORs定量分析的临床意义  

THE SIGNIFICANCE OF AgNORs QUANTITATIVE ANALYSIS IN PATIENTS WITH MALIGNANT LYMPHOMA

作　　者：卢洁[1] 谷仁凯[1] 徐贤秋 刘毅[1] 

机构地区：[1]青岛医学院,青岛中国纺织工人疗养院

出　　处：《白血病》1995年第4期214-216,共3页

摘　　要：采用核仁组成区相关嗜银蛋白（ＡｇＮＯＲｓ）染色技术，对７１例淋巴结良、恶性病变的组织石蜡切片进行ＡｇＮＯＲｓ定量研究。结果显示：３２例淋巴结良性病变平均每个细胞核内ＡｇＮＯＲｓ计数为１．７９±０．５９，３１例恶性淋巴瘤平均每个细胞核内ＡｇＮＯＲｓ计数为６．６２±３．０２，８例淋巴结内低分化转移癌平均每个细胞核内ＡｇＮＯＲｓ计数高达１３．７７±５．２４，表明良、恶性病变ＡｇＮＯＲｓ计数差别十分显著（Ｐ＜０．０１）。２０的非何杰金淋巴瘤（ＮＨＬ）中，低度恶性组ＡｇＮＯＲｓ计数为３．７９±１．４６，而中、高度恶性组ＡｇＮＯＲｓ计数为平均每个细胞核内ＡｇＮＯＲｓ８．２８±２．５８，两组比较差别有显著意义（Ｐ＜０．０１），显示低分化的恶性肿瘤，具有更加恶性的生物学行为。By using silver colloid technique,we studied the nucleolarorganizerregionassociatedargyrophilic proteins( AgNORs)quantitatively in the biopsy lymph nodes of 7 1 patients.Theresults showed that the AgNORs counts were 1. 79 ± 0. 59 in 32 lymph nodes with benignchanges,6. 62± 3. 02 in lymph nodes with malignant lymphoma, and the difference is significant(P<0.01). In Non-Hodgkin’s lymphoma, the AgNORs counts were significantly higher incases of low-degree differentiation than in cases of high-degree differentiation (P<0.01). Thistechnique may be valuable in the study of differential diagnosis between benign and malignantlymph nodes and in the grading of tumours.

关 键 词：淋巴肉瘤 AGNORS 病理 

分 类 号：R733.402[医药卫生—肿瘤]