椎基底动脉脑缺血动物模型  

AN ANIMAL MODEL OF VERTEBRO-BASILAR ARTERY ISCHEMIA

作　　者：李学佩[1] 马芙蓉[1] 王伟[1] 马铁民[1] 

机构地区：[1]北京医科大学第三医院耳鼻咽喉科,北京医科大学病理生理教研室

出　　处：《北京医科大学学报》1995年第6期427-429,共3页Journal of Peking University(Health Sciences)

基　　金：卫生部科研基金

摘　　要：报告结扎一侧颈总动脉、部分阻断基底动脉所造成的椎基底动脉脑缺血动物模型。血管阻断后基底动脉内血细胞流动减少、血流变慢；脑干电图示波幅减低、频率减低；脑干听诱发电位出现反应阈增高、潜伏期延长和波幅减低；耳蜗血流减低４７．４１ＡＢＬ％。证明这是一个研究椎基底动脉供血障碍基础和临床的实用、有效和符合临床特点的动物模型。his is the first report on an animal model of VBI.The severity of ischemia was established by brainstem elec-troencephalogram,ABR and laser Doppler flowmetry etc.When these vessels were obstrticted,all of them have been obviously changed.It is proved to be a useful and effective animal model,conforming to the clinical character-istics.In conseqence,this model is particularly suited for basic or clinical experiments of VBI and inner ear.

关 键 词：脑缺血 椎底动脉 供血不足 动物模型 

分 类 号：R743.31[医药卫生—神经病学与精神病学]