串珠镰刀菌素对软骨细胞作用的实验研究  

The Experimental Study of Moniliformin Effects on the Chondrocytes

作　　者：曹峻岭[1] 郑滨[1] 张矢远[1] 莫东旭[1] 

机构地区：[1]西安医科大学地方性骨病研究所

出　　处：《地方病通报》1995年第4期5-7,共3页Endemic Diseases Bulletin

基　　金："八.五"国家重点计划攻关课题

摘　　要：本实验用不同浓度的串珠镰刀菌素（ＭＯＮ）作用于体外培养不同时期的兔关节软骨细胞，动态观察ＭＯＮ对软骨细胞结构和生长代谢功能的影响。结果显示ＭＯＮ影响软骨细胞ＤＮＡ的合成和细胞的分裂增殖，特别在细胞培养的早期，作用更为明显；同时也影响到细胞的结构和代谢功能。ＭＯＮ的作用机理和与大骨节病的关系有待进一步研究。The experiment by culturing rabbit articular chondrocytes in the media with different of monili-formin(MON) was conducted to observe the effects of MON on the growth, metabolism and ultrastructureof the chondrocytes in different culture times. The results showed that MON could restrain the DNA synthe-sis and cellular growth of chondrocytes,that the effect of damage was more evident, particularly at the earlystage of cultural chondrocytes. The ultrastructure and the glucuronate metabolism of the chondrocytes werealso affected by MON. The effect mechanism of MON and its relationship with Kashin─Beck disease needfurther investigation.

关 键 词：真菌毒素 串珠镰刀菌素 软骨细胞培养 大骨节病 

分 类 号：R684.102[医药卫生—骨科学]