野木瓜甙YM_(10)和YM_(12)的结构  

THE STRUCTURES OF YEMUOSIDE YM_(10) AND YM_(12) FROM STAUNTONIA CHINENSIS

作　　者：王淮滨[1] 于德泉[1] 梁晓天[1] 渡边修治 玉井正晴 大村贞文 

机构地区：[1]中国医学科学院药物研究所,北京100050 [2]大正制药株式会社

出　　处：《药学学报》1989年第6期444-451,共8页Acta Pharmaceutica Sinica

摘　　要：从野木瓜(Stauntonia chinensis DC.)中分离得到二个去甲五环三萜皂甙化合物,经化学和光谱分析,分别鉴定为3-O-α-L-吡喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖-30去甲齐墩果-12,20(29)-二烯-28-羧酸-28-O-α-L-呲喃鼠李糖-(1→4-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖酯,命名为野术瓜甙YM10(Ⅰ)和3-O-α-L-呲喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖-30-去甲齐墩果-12,20(29)-二烯-28-羧酸-28-O-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖酯,命名为野木瓜甙YM_(12)(Ⅱ)。Ⅰ和Ⅱ均系首次从植物中得到的新化合物。Two new nortriterpenoid saponins, named yemuoside YM_(10) (Ⅰ) and YM_(12) (Ⅱ) , were isolated from Stauntonia chinensis Decne. A new prosaponin (Ⅵ) was isolated from the cleavage of ester-glycoside linkage. Their chemicaI structures were elucidated by means of chemical and spectrometric analysis.Yemuoside YM_(10) (Ⅰ): C_(58)H_(92)O_(25), a white powder, mp 215～8219℃ (dec), [α]_D^(20)-4.41° ( c 0.272, CH_3OH). Its structure was found to be 28-O-α-L-rhamnopyanosyl- (1→-4) -β-D-glucopyranosyl- (1→-6) -β D-glucopyranosyl ester of 3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-30-norolean -12, 20 (29) -dien-28-oic acid.Yemuoside YM_(12) (Ⅱ)- C_(52)H_(82)O_(21), a white powder, rap 200～204℃ ( dec. ), [α]_D^(20)+10.12° ( c 0.346, CH_3OH). Its structure was found to be 28-O-β-D-glucopyranosyl- (1→6) -β-D-glucopyranosyl ester of 3-O-α-L-rhamnopyranosyl- (1→-2) -α-L-arabinopyranosyl-30-norolean - 12, 20 (29) -dien - 28 - oic acid.Prosaponin (Ⅳ) :C_(40)H_(62)O_(11), a white powder, mp 243～246℃ (dec.), [α]_D^(22) +12.13° ( c 0.128, CH_3OH). Its strvcture was found to be 3-O-α-L-rhamnopyranosyl- (1→2) -α-L-arabinopyranosyl-30-norolcan 12, 20 (29)-dien-28-oic acid.

关 键 词：野木瓜 野木瓜甙 结构 

分 类 号：R932.11[医药卫生—生药学]