重组人睫状神经营养因子对大鼠胶质细胞瘤C_6细胞系生长的影响  

Effects of recombinant human ciliary neurotrophic factor on the growth of rat glioma C_6 cell line

作　　者：张树辉[1] 詹镕洲[1] 田野萍[1] 何成[1] 王建军[1] 

机构地区：[1]第二军医大学基础医学部病理学教研室,第二军医大学基础医学部免疫学教研室,第二军医大学基础医学部神经生物学教研室

出　　处：《第二军医大学学报》1995年第5期409-411,共3页Academic Journal of Second Military Medical University

摘　　要：本研究观察了重组人睫状神经营养因子（ｒｈＣＮＴＦ）对大鼠胶质瘤Ｃ６细胞系生长的影响。发现ｒｈＣＮＴＦ２０～２０００ｎｇ／ｍｌ可抑制Ｃ６细胞增殖，细胞形态发生明显改变，且具有剂量─时间效应。此外，ｒｈＣＮＴＦ还可诱导Ｃ６细胞分泌少量ＩＬ─６。结果表明，ｒｈＣＮＴＦ对Ｃ６细胞的抑制作用可能与其参与瘤细胞的生长调节有关，推测ｒｈＣＮＴＦ作为一种细胞调节因子对胶质瘤具有潜在治疗作用。This study was designed to observe the effect of recombinant human ciliary neurotrophic factor(rhCNTF) on the growth of rat glioma C_6 cell line.The results showed that rhCNTF 20～2000 ng/ml could inhibit the proliferation of rat glioma C_6 cell line in a dose-time dependent fashion,with distinctive morphological changes in the cells.In addition rhCNTF could induce lower production of IL-6 secreted by C_6 cells.Those suggest that the effect of rhCNTF on the growth of rat glioma C_6 cells might involve an unkonwn regulative mechanism for the tumor cell growth,and it may play a potential role as a cellular regulator in the treatment of glioma.

关 键 词：睫状神经 营养因子 白细胞介素 胶质瘤 C6细胞系 

分 类 号：R730.264[医药卫生—肿瘤]