人胃、十二指肠粘膜SS，AVP，EK和β－EP含量测定及其临床意义  

Clinical significances of contents of somatostatin,argovasopressin,enkephalin and β-endorphin in gastroduodenal mucosa

作　　者：张宏博[1] 张忠兵[1] 张学庸[1] 胡家露[1] 樊代明[1] 

机构地区：[1]西京医院消化内科

出　　处：《第四军医大学学报》1995年第3期208-210,共3页Journal of the Fourth Military Medical University

摘　　要：作者应用放免分析法对２４例十二指肠溃疡（ＤＵ），１５例胃溃疡（ＧＵ）患者胃、十二指肠粘膜进行了生长抑素（ＳＳ），精氨酸加压素（ＡＶＰ）、脑啡肽（ＥＫ）和β－内啡肽（β－ＥＰ）含量测定．同时以２０例慢性浅表性胃炎（ＣＳＧ）为对照．结果表明，ＤＵ患者球、窦和体部粘膜ＳＳ含量（依次为１５３．５±２７．５，３３０．９±２３．９和１７７．１±３０．９ｐｇ／ｍｇ）显著低于（Ｐ＜０．０５）对照（依次为２５３．７±３４．２，５８８．９±８５．３和２８８．８±４０．５ｐｇ／ｍｇ），ＥＫ（依次为９８．６±１３．２，１０８．２±１６．５和５８．５±１０．３）和β－ＥＰ（依次为１１３．０±２２．６，８８．７±１６．８和８２．８±１８．８ｐｇ／ｍｇ）显著高于（Ｐ＜０．０１）对照（ＥＫ依次为５０．１±８．８，６２．９±１１．４和３０．９±３．０；β－ＥＰ依次为８２．３±８．１，３９．８±６．８和４９．８±９．１）．ＤＵ患者球部粘膜ＡＶＰ（５２．３±７．０ｐｇ／ｍｇ）显著高于（Ｐ＜０．０５）ＣＳＧ（３７．７±４．３ｐｇ／ｍｇ）．ＧＵ组上述激素含量与对照组比较均无显著差异．提示：①ＡＶＰ，ＳＳ，ＥＫ和β－ＥＰ在人胃、十二指肠皆有分布；②粘?The contents of somatostatin(SS),argovasopressin(AVP),enkephalin(EK)and β-endorphin(β -EP)were determined by means of radioimmunoassay in mucosa biopsied from the fundus and antrum ofstomach,and duodenal bulb in 24 patients with duodenal ulcer (DU),15 gastric ulcer (GU),and 20 chronicsuperficial gastritis (CSG).In DU group,levels(pg/mg wet tissue as follow) of SS in fundus(177.1±30.9),antrum(330.9±23.9),and duodenal bulb(153.5±27.5) was significantly decreased (P<0.05)compared to that in CSG(288.8±40.5 in fundus, 588.9±85.3 in antrum and 253.7±34.2 in duodenal bulb),respectively. Levels of EK and β-EP in the fundus(58. 5±10.3 and 82.2±18.8),antrum (108. 2±16.5 and 88.7±16. 8) ,and duodenal bulb(98.6±13. 2 and 113.0±22.6)were remarkably increased (P< 0.01)compared to those in CSG(30.9±3. 0 and 49.8±9. 1 in fundus, 62.9±11.4 and 39.8±6. 8 in antrum,and 50.1±8.8 and 82.3±8. 1 in duodenal bulb),respectively. In duodenal bulb of DU,the content of AVP(52.3 ±7.0)was significantly higher than that in the CSG (37.7±4.3P<0.05).But the same re-sult was not obtained in patients with GU (P>0. 05).It is suggested that:(1)immunologically reactive SS,AVP,EK and β-EP are all widely distributed in gastroduodenal mucosa of adult human subjects;(2)lower level of SS and higher levels of AVP, EK and β-EP in the gastroduodenal mucosa may be associated with the pathogenesis of DU;(3) higher levels of AVP, EK and β-EP may be related to reduction of SS in gastroduo-denal mucosa.

关 键 词：胃肠激素 消化性溃疡 生长抑素 精氨酸加压素 

分 类 号：R573.102[医药卫生—消化系统]