大鼠脑缺血后各脑区单胺类神经递质的动态变化  

Sequent Changes of Monoamine in Different Regions of Rat Brain after Cerebral Ischemia

作　　者：张志坚[1] 慕容慎行[1] 林新霖[1] 许国英[1] 吴秀丽 

机构地区：[1]福建医学院附属第一医院神经病学研究室

出　　处：《福建医学院学报》1995年第1期7-9,共3页

摘　　要：采用大鼠四血管关闭全脑缺血方法，动态观察４８只大鼠脑的皮质、基底节与丘脑以及脑干中去甲肾上腺素（ＮＡ）和多巴胺（ＤＡ）在不同缺血时间含量的变化．结果显示大鼠脑缺血时存在脑单胺递质的紊乱，其中ＮＡ的含量在各脑区多为升高，且相互之间呈正相关关系；ＤＡ在脑干与皮质降低，在基底节与丘脑呈双向波动，各脑区的含量变化不存在相关关系。在皮质ＮＡ与ＤＡ变化呈负相关，在基底节与丘脑则呈正相关，在脑干则不相关。这些发现提示脑缺血时各脑区的单胺递质有着不同的变化。The sequent changes of noradrenaline (NA)and dopamine (DA)in cortex,brain stem,basial ganglia and thalamus of forty eight rats were observed with the four-vessel occlusion method.The results showed that there was central monoamine neurotransmitters disorder while rat brain was ischemic,in which the levels of NA were increased in most brain regions,and there were positive correlations among these regions.The levels of DA were decreased in cortex and brain stem,and waved in basial ganglia and thalamus,and there was no correlation to be found among these regions.There were different correlations to be found between NA and DA in different brain regions.These findings suggest that there were specialities concerning the monoamine distribution in different ischemic brain regions

关 键 词：大鼠 脑缺血 去甲肾上腺素 多巴胺 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]