N－三苯锗丙酰基－α－氨基膦酸酯的合成及其性质研究  

The Synthesis and Properties of N-(β-Ttiphenylgermalyl) propionyl-α-amino-methylphosphonates

作　　者：陈茹玉[1] 毛丽娟[1] 

机构地区：[1]南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1995年第6期892-895,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金资助课题

摘　　要：合成了两个系列含有三苯锗丙酰基的α－氨基膦酸酯类化合物，研究了空阻大的α－氨基膦酸酯与β－三苯锗丙酸的缩合方法、反应条件及反应机理．生物活性测定结果表明，这类衍生物与相应的α－氨基膦酸衍生物相比有显著抗癌活性和抗烟草病毒活性。In this paper,two series of N-(β-triphenylgermanyl)propionyl-α-aminomethylphosphonates have been synthesized and both conditions and mechanism of the condensation reaction of sterically hindered α-aminomethylphosphonate with βtriphenylgermanyl propionic acid were studied. Preliminary bioassays indicate that the title compounds compared with corresponding α-amino-methylphosphonates have more significant antitumor and anti-TMV properties.

关 键 词：Α-氨基膦酸酯 β-三苯锗丙酸 缩合反应 抗癌活性 结构鉴定 

分 类 号：O627.51[理学—有机化学] O627.42[理学—化学]