γ－［N_1－取代－1，4，5，6－四氢（及1，6－二氢）－6－氧－3－哒嗪酰胺基］丁酸乙酯类化合物的合成  

Synthesis of Ethyl Esters of γ-[N_1-Substituted-1,4,5,6-tetrahydro(or 1,6-dihydro)-6-oxo-3-pyridazinamide]butyric Acid

作　　者：许凤荣[1] 王书玉[1] 徐萍[1] 黎辉 胡长风[1] 欧阳荔[1] 

机构地区：[1]北京医科大学药学院

出　　处：《高等学校化学学报》1995年第8期1254-1256,共3页Chemical Journal of Chinese Universities

摘　　要：γ－［Ｎ_１－取代－１，４，５，６－四氢（及１，６－二氢）－６－氧－３－哒嗪酰胺基］丁酸乙酯类化合物的合成许凤荣，王书玉，徐萍，黎辉，胡长风，欧阳荔（北京医科大学药学院、分析计算中心波谱室，北京，１０００８３）关键词６－氧－３－哒嗪酸，哒嗪类衍生物，...Tetrahydro-6-oxo-3-pyridazinecarboxylic acid(I) was obtained by the condensate of α-oxoglutaric acid with hydrazine hydrate.I was dehydrogenated to give 1,6dihydro-6-oxo-3-pyridazinecarboxylic acid(Ⅱ).Under the phase transfer catalysis,Ⅲ and Ⅳwere converted into corresponding N1-substituted-1,4,5,6-tetrahydro-6-oxo-3-pyridazinecarboxylic acids(Ⅴ)and N1-substituted-1,6-dihydro-6-oxo-3-pyridazinecarboxylic acids(Ⅵ),which then condensated with ethyl ester of γ-amino butyric acid.Ten ethyl esters of γ-[N1-substituted-1,4,5,6-tetrahydro(or 1,6-dihydro)-6-oxo-3-pyridazinamide]butyric acid(Ⅶa c and Ⅷa e)were synthesized. All compounds synthesized here have not been found in the literature.

关 键 词：哒嗪酸 相转移催化 丁酸乙酯 

分 类 号：O626.4[理学—有机化学] O623.624.1[理学—化学]