Gd－DTPA氨基酸、短肽衍生物的合成及其磁共振成像造影性能的研究  

Studies on the Synthesis and Relaxivity of Amino Acids and Oligopeptides of Gd-DTPA Derivatives

作　　者：罗毅[1] 卓仁禧[1] 范昌烈[1] 

机构地区：[1]北京大学化学与分子工医学院,武汉大学化学系

出　　处：《高等学校化学学报》1995年第9期1476-1479,共4页Chemical Journal of Chinese Universities

基　　金：国家863计划项目资助

摘　　要：合成了一系列二乙三胺五乙酸（ＤＴＰＡ）的疏水性氨基酸、短肽衍生物的Ｇｄ（Ⅲ）螯合物，研究了其磁共振成像造影性能。结果表明：螯合物的急性毒性与Ｇｄ－ＤＴＰＡ相当，自旋－晶格弛豫性能Ｒ＿１比Ｇｄ－ＤＴＰＡ略高。Ｇｄ－ＤＴＰＡ，氨基酸，短肽，急性毒性。The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems. Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting, Gd-DTPA is the first MRI contrast agent clinically used, the chelates of Gd(Ⅲ) and DTPA derivatives were more selective and less toxic than Gd-DTPA. In this paper,a series of amino acids and oligopeptides of Gd-DTPA derivatives were synthesized, The structures of these chelates were confirmed by IR and elementary analysis. Toxicity of chelate was almost the same as Gd-DTPA.The spin-lattice relaxivity (R1) of these chelates was a little bit larger than that of Gd-DTPA.

关 键 词：氨基酸 短肽 DTPA 磁共振成像 镉螯合物 

分 类 号：O614.242[理学—无机化学] R445.2[理学—化学]